Bobby is sitting at his desk with a pile of books in front of him. Sam is sitting in a chair in the opposite corner talking to Dean, who is standing. Jamie is leaning against the wall between them.

"Well, then tell me what else it could be."

Dean looks back at her annoyed. "Look, all I know is I was not groped by an angel."

"Okay, look, Dean. Why do you think this Castiel would lie to you about it?" Sam asks from his chair.

"Maybe he's some kind of demon. Demons lie."

Jamie rolls her eyes. "That's blasphemy, Dean."

"I don't give a damn, Jamie."

Bobby looks up from his books at the siblings.

Sam gets up. "A demon who's immune to salt rounds and devil's traps... and Ruby's knife? Dean, Lilith is scared of that thing!"

"Don't you think that if angels were real, that some hunter somewhere would have seen one... at some point... ever?"

Jamie raises her hand. "Hi. Jamie Winchester, hunter. Saw the angel."

Sam nods. "Yeah. And so did you, Dean."

"I'm trying to come up with a theory here. Okay? Work with me."

Jamie moves over to Sam. "We are."

"We have a theory."

Dean shakes his head. "Yeah, one with a little less fairy dust on it, please."

"Okay, look. I'm not saying we know for sure."

Jamie turns to her twin. "I am…"

Sam smirks. "Well, I'm just saying that I think we –"

"Okay, okay. That's the point. We don't know for sure, so I'm not gonna believe that this thing is a freaking Angel of the Lord because it says so!" Dean throws his arms out in frustration.

Jamie uncrosses her arms and copies Dean's outward sign of frustration. "I'm standing right here, Dean. I can sense evil. Castiel made me drop to my damn knees and speak Latin. I would say that makes him pretty damn creditable."

Bobby finally speaks up. "You three chuckleheads want to keep arguing religion, or do you want to come take a look at this?" The siblings walk over to Bobby's desk. He eyes each of them before patting his books. "I got stacks of lore - Biblical, pre-Biblical. Some of it's in damn cuneiform. It all says an angel can snatch a soul from the pit."

"Grip them tight and raise them from perdition." Jamie says with a smirk. Dean glares at her.

"What else?"

"What else, what?"

"What else could do it?"

"Airlift your ass out of the hot box? As far as I can tell, nothing."

Sam looks up. "Dean, this is good news."

"How?"

"Because for once, this isn't just another round of demon crap. I mean, maybe you were saved by one of the good guys, you know?"

"Okay. Say it's true. Say there are angels. Then what? There's a God?"

Jamie looks up from where she's going through Bobby's books. "Of course."

Bobby nods in agreement. "At this point, Vegas money's on yeah."

Dean sighs. "I don't know, guys."

Jamie takes a step forward. "Dean…explain exorcisms to me, then. Explain holy water. My freakin rosary beads. If there isn't a God then why does this crap work on demons?"

Sam moves towards Dean's other side. "Okay, look. I know you're not all choirboy about this stuff, but this is becoming less and less about faith and more and more about proof."

"Proof?"

"Yes."

"Proof that there's a God out there that actually gives a crap about me personally? I'm sorry, but I'm not buying it."

Jamie walks over to him. "Why not?"

Dean looks down at her and finally relents a little. "Because why me? If there is a God out there, why would he give a crap about me?"

Sam sighs. "Dean…"

"I mean, I've saved some people, okay? I figured that made up for the stealing and the ditching chicks. But why do I deserve to get saved? I'm just a regular guy."

Sam looks over at him. "Apparently, you're a regular guy that's important to the man upstairs."

Jamie smirks. "Ecce servus domini."

Dean looks at his sister. "What the hell does that mean?"

"Servant of the Lord."

"Well, that creeps me out. I mean, I don't like getting singled out at birthday parties, much less by... God."

Sam looks at Jamie and Jamie looks back at him. Sam shrugs. "Okay, well, too bad, Dean, because I think he wants you to strap on your party hat."

"Fine. What do we know about angels?"

Bobby picks up a pile of fat and weighty looking books and puts them in front of Dean. "These are the ones in English. Start reading."

Dean points a pile of books nearby. "What about those?"

Bobby picks up one. "Latin."

Dean looks at the pile of books, and turns towards Sam. "You're gonna get me some pie." He turns to Jamie. "And you're gonna help me translate." He grabs a book from the top of the pile. Jamie takes one of the Latin books.

Not long after Sam leaves Bobby walks into the room where Dean and Jamie were both curled up with books. "Not that this isn't a heartwarming sight but…"

"Trouble Bobby?" Jamie asks, looking up from her book.

"Yeah, missing hunters."

"Damn." Dean says. "How many?"

"Enough that we outta go check it out."

"Alright." Jamie gets up. "I'll go call Sam and tell him to get back here."

When Sam gets back, Dean approaches the driver's side of the car, as Bobby heads to his own car. Jamie gets in the backseat with a bunch of books. "Scoot over. Yeah." Dean grabs the bag of food Sam bought back and looks inside it. "Dude?"

"Yeah?" Sam asks.

"Where's the pie?"

Jamie grabs the bag from Dean. "Who cares, I'm starving."

When they get to Olivia's house, Bobby enters first, armed with a gun, followed by Dean, Jamie and Sam who are also armed. "Olivia?" Bobby calls. They see her dead and covered in blood on the floor. Bobby walks away, out of the room.

Jamie shakes her head. "Bobby?" Dean asks, looking around the corner.

Sam points to the doorway. "Salt line."

The siblings look around the room. Jamie sees the Emf. "Guys."

Dean picks up the device. "Olivia was rocking the EMF meter."

Sam nods. "Spirit activity."

"Yeah - on steroids. I never seen a ghost do this to a person." Dean says. Jamie looks worried. Bobby enters the room again, his phone in his hand. "Bobby, you all right?"

"I called some hunters nearby..."

Dean nods. "Good. We can use their help."

"...except they ain't answering their phones either."

"Oh." Jamie rubs her temples. "Oh." She says again. Dean takes a step towards her.

Sam looks at his sister. "Something's up, huh?"

"You think?" Bobby walks out of the room and the Winchesters look concerned.

Dean and Sam get out of the Impala and go inside a white creepy looking house. Jamie gets out and leans against the car, one of the angel books in her hand. She's wearing a utility belt strapped at her waist and one hip, where Ruby's knife is visible. She's on her phone. "Robin, it's Jace Winchester. Please tell me Aaron is home. I know he doesn't want to talk me, but is he at least home? Okay. Okay. Just…there is something going on and you two need to get somewhere safe for awhile. Someone or something is killing off hunters. Yeah, I'm gonna call Dan in a minute and tell him the same thing. Alright. Bye Robin." She hangs up her phone and dials Dan's number. The phone rings until the machine answers. "Damnit. Dan, it's Jace. Something is killing hunters and you need to call me back the second you get this. Please be alive." A cold wind sends a shiver down her spine. Andrew appears at her side, covered in blood. Jamie gasps and drops her phone. "AJ? What the hell?"

"Jace…why didn't you protect me?"

Jamie takes a step back. "I tried. I couldn't."

Andrew walks towards her. "We should have never been there, Jace. You walked us right into a trap."

Jamie circles the car, breathing heavily. "So beautiful. I loved you. And you betrayed me." Andrew goes to touch her. She sees a brand on his arm. Suddenly Castiel appears. He holds his hand out and Andrew screams and disappears.

"Castiel. What the hell is going on?" Castiel disappears. Jamie looks over and sees Dean and Sam are walking down the stairs, exiting the house. Dean is on the phone. Jamie opens the door to the Impala and gets inside quickly. Her brothers get to the car. Jamie is sitting in the backseat with her book. Sam looks back at her.

"You okay?"

Jamie nods. "I got through to Aaron and Robin, but I think it already got Dan."

"I'm sorry." Sam tells her. She nods again.

Dean gestures to her phone. "Did you find out anything?"

"Nothing helpful. Robin didn't know anything and Aaron still isn't speaking to me."

Dean Jamie and Sam are driving, and pull up to a stop at a service station. The car stops, and Sam puts the gas pump in the car. He walks to the restroom while the gas is pumping. Dean is asleep in the passenger seat of the car. Jamie is curled up in the backseat reading. She's quiet for a few moments and then looks up. "Dean…" She puts the book down climbing over the seat. "Dean." She shakes his shoulder and he wakes up with a start. "Dean, something is after Sam."

Dean immediately gets out of the car and Jamie scrambles after him. She points to the restroom and the two siblings rush to the door. Jamie flings it open and they enter. Sam is on the floor and Henriksen is standing over him. Dean shoots at him and the ghost disappears. Jamie rushes over to Sam and helps him up.

"Come on, we gotta get outta here!" Dean yells. He helps Jamie get Sam into the Impala.

Jamie is driving. Dean is on the phone. Sam is in the back seat with bruises on his face. Dean is looking at his phone. "Damn it, Bobby! Pick up!"

"Damnit, Bobby." Jamie grips the steering wheel.

Dean looks over at Sam. "How you feeling, huh? How many fingers am I holding up?"

"None. I'll be fine, Dean."

"Henriksen?"

"Yep."

"Why? What did he want?"

"Revenge, 'cause we got him killed."

"Sam."

"Well, we did, Dean."

Jamie sighs. "I saw Andrew."

Dean looks over at his sister, astonished. "What?"

Jamie nods. "When you guys were in the house. Andrew's ghost came at me."

Sam moves closer to them. "Jamie, why didn't you tell us?"

Jamie keeps her eyes on the road. "Nothing happened to me, that's why. I mean, he tried but…"

"But what?" Dean demands.

"Nothing. He didn't do anything to me. But I still saw him." She pauses. "And I got him killed too."

Dean shakes his head. "All right. Stop right there. Whatever the hell is going on, it's happening to us now, okay? I can't get ahold of Bobby, so if you two are not thinking answers, don't think at all."

It's light out when they get to Bobby's house. The siblings enter the house, guns cocked and ready.

"Bobby?" Dean asks. They find the iron poker on the ground. He gestures to the stairs. "I'll go. You two check outside."

Sam and Jamie walk through the junkyard. Bobby is in a car with the ghosts of two girls, who are keeping him quiet.

"Bobby?"

"Bobby? Bobby?"

"Bobby!" Jamie rubs her forehead.

Sam looks at her. "Something coming?"

"Something's here…" She and Sam look around. Sam's breath becomes visible. Jamie looks at him and then looks toward the car Bobby's in.

"Bobby?" She and Sam get closer. "We're here, Bobby."

"Sam…" Jamie nods toward the car. She cocks her gun. Sam cocks his. They move away from each other and slowly walk towards it. "We're coming Bobby, just a second!" Sam tries to open the door. Jamie grabs a crowbar and hands it to Sam.

"Hold on, Bobby!" Sam uses the crowbar to pry open the doors to the car where Bobby is being held. The Girls push him and Jamie backwards and they land on another car below, bleeding. One of the Girls jumps on Sam. Jamie sees another crowbar and it flies into her hand. She hits the girl with it, while Bobby does the same with the other girl. They disappear.

Dean, Jamie, Sam and Bobby are in the study. Sam looks up at his siblings. "So, they're all people we know?"

Jamie nods. "Not just know. People we couldn't save."

Dean sighs. "Yeah. Hey, I saw something on Meg. Did she have a tattoo when she was alive?"

Sam thinks for a moment. "I don't think so"

"It was like a-a mark on her hand - almost like a brand."

Sam looks at him. "I saw a mark, too, on Henriksen."

Jamie nods. "There was one on AJ too."

Bobby turns to the siblings. "What did it look like?"

"Uh, paper?" Sam takes offered paper and starts sketching the mark. "Thanks." He holds the drawing up for Dean and Jamie to compare.

"That's it." Dean says.

Jamie cringes. "Oh yeah."

Bobby takes a look at it. "I may have seen this before. We got to move."

"Whoa." Sam says as Bobby brushes past him.

"Follow me."

The siblings start to follow Bobby downstairs. "Okay, where are we going?" Sam asks.

"Some place safe, you idiot."

Jamie grabs Sam's hand. "Come on Sam."

"Jamie, here." Bobby picks up some books and hands them to Jamie, he leads her, Sam and Dean to a basement room, which is made entirely of iron and covered with pentagrams and Devil's traps.

Jamie gasps looking around. "Holy…"

"Bobby, is this..."

"Solid iron. Completely coated in salt. 100% ghost-proof."

Jamie and Dean look impressed.

"You built a panic room?" Sam asks.

Bobby shrugs. "I had a weekend off."

"Bobby."

"What?"

"You're awesome. Oh." Dean sees a poster of a swimsuit model. Jamie whacks him on the shoulder.

Awhile later Sam Jamie and Dean are making salt and iron bullets. Jamie also has a book open.

Sam looks over at her. "You're still reading that angel book?"

"Yup."

Sam grins. "You remember Dad trying to teach us Latin?"

"Yeah. I remember Dean couldn't pronounce half the words worth a damn."

"I can't believe it stayed with you. What were we, seven when he started teaching us?"

Jamie smirks. "Well I was raised in a frickin convent. What do you think read to past the time, comic books? No. I read everything on the supernatural the nuns had and then some."

"You're intense."

"Damn straight."

"See, this is why I can't get behind God." Dean finally says.

Jamie groans. "Not again."

Sam looks over at their brother. "What are you talking about?"

"If he doesn't exist, fine. Bad crap happens to good people. That's how it is. There's no rhyme or reason - just random, horrible, evil - I get it, okay. I can roll with that. But if he is out there, what's wrong with him? Where the hell is he while all these decent people are getting torn to shreds? How does he live with himself? You know, why doesn't he help?"

Bobby looks up. "I ain't touching this one with at 10-foot pole."

Jamie nods. "Join the club."

"Yeah."

"Found it." Bobby holds up his book.

"What?"

"The symbol you saw - the brand on the ghosts... "

Sam goes over to him. "Yeah?"

"Mark of the Witness."

"Jesus Christ!"

Dean looks over at his sister. "Jamie?"

Jamie gets off the table and goes over to Bobby. She starts looking through the pile of books.

Sam looks confused. "Witness? Witness to what?"

"The unnatural. None of them died what you'd call ordinary deaths. See, these ghosts - they were forced to rise. They woke up in agony. They were like rabid dogs. It ain't their fault. Someone rose them... on purpose. "

"Who?"

"Do I look like I know? But whoever it was used a spell so powerful it left a mark, a brand on their souls. Whoever did this had big plans. "

Jamie holds up another book. "It's called "the rising of the witnesses." It figures into an ancient prophecy.

Dean gets up. "Wait, wait. What - what book is that prophecy from?"

"Jamie?"

Jamie opens the book she's holding. "Revelations. This is a sign, boys."

"A sign of what?" Dean and Sam ask together.

Bobby and Jamie look at each other. "The apocalypse."

"Apocalypse? The apocalypse, apocalypse? The four horsemen, pestilence, $5-a-gallon-gas apocalypse?"

"That's the one. The rise of the witnesses is a - a mile marker."

Jamie shakes her head. "A seal."

Sam takes a breath. "Okay, so, what do we do now?"

Dean starts counting things off. "Road trip. Grand Canyon, Star Trek Experience. Bunny Ranch."

Jamie smacks him in the head with a book. "Dean!"

Bobby chuckles. "First things first. How about we survive our friends out there?"

Dean groans, rubbing his head. "Great. Any ideas aside from staying in this room until Judgment Day?"

"It's a spell." Bobby indicates the paper in front of him. "Sends the witnesses back to rest. Should work."

Sam looks skeptical. "Should. Great."

Bobby nods to Jamie. "If Jamie translates it correctly. I think I got everything we need here at the house."

Dean looks around. "Any chance you got everything we need here in this room?"

"So, you thought our luck was gonna start now all of a sudden?" Bobby asks.

Jamie looks at her brothers. "Spell's got to be cast over an open fire."

Sam nods. "The fireplace in the library."

"Bingo."

Dean shakes his head. "That's just not as appealing as a, uh, ghost-proof panic room, you know?"

SAM, Jamie, DEAN and BOBBY prepare to leave the panic room. Bobby turns to the siblings. "Cover each other. And aim careful. Don't run out of ammo until we're done, or they'll shred you. Ready?" They make their way out of the room, and head towards the stairs. A ghost sits on the stairs, a young man in his early 20s with curly hair.

"Hey, Dean. You remember me?"

"Ronald, huh? With the laser eyes? I wish I could say it's good to see you."

"I am dead because of you. You were supposed to help me!"

Jamie shoots at Ronald. "If you're gonna shoot, shoot. Don't talk."

They make their way to the living room. Sam creates a salt circle and Dean starts the fire. Jamie opens the book and scans over the words.

Bobby turns to Sam. "Upstairs, linen closet - red hex box. It'll be heavy."

"Got it."

The two girls appear in the living room again. Jamie sees them. "Dean!"

"Bobby." One of the girls says. Dean shoots at them.

Bobby turns to him. "Kitchen. Cutlery drawer. It's got a false bottom. Hemlock, opium, wormwood."

"Opium?"

"Go!"

The girls reappear as Dean leaves for the kitchen. Bobby is drawing with chalk on the desk and tries to focus on this while the girls are there. Jamie is writing something down on a sheet of paper.

"Bobby. You walked right by us while that monster ate us all up."

"You could have saved us."

Jamie picks up her gun and shoots at the girls. Andrew appears.

"Jace…"

Bobby grabs his gun and shoots him.

Jamie looks up. "Thanks."

Dean is in the kitchen looking for the false bottom in the drawer. The doors to the kitchen close suddenly. Jamie looks up. "Dean?"

"I'm all right, Jamie! Keep working!" Dean tells her. Jamie looks back down at the paper while Dean wrestles with another ghost. Eventually Sam helps Dean up and they carry the hex box and other ingredients to the library.

"I got it. I'm good to go, Bobby." Jamie tells him.

"Good." He takes the hex box. Ronald appears again as Dean is reloading his gun.

"Ronald. Hey, come on, man. I thought we were pals."

"That's when I was breathing. Now I'm gonna eat you alive."

"Well...come on, I'm not a cheeseburger." Dean cocks his gun and points it at Ronald, but Ronald has vanished. Jamie recites some Latin words and the windows blow open and a wind fills the room. The wind moves the salt so they are no longer protected by it. Jamie hands Bobby her gun. Meg appears and Sam quickly shoots at her, as Jamie continues to recite the spell. Ronald appears and they shoot at him. Andrew appears and Bobby shoots him. Sam and Dean continue to fire as the ghosts appear. Henriksen knocks Dean's gun out of his hands when he is reloading, and approaches him. Dean grabs another gun, and shoots it, only to find it empty. He quickly picks up an iron rod and hits at Henriksen. Meg appears and pushes Sam against the wall, trapping him there with a desk. Sam tries to push the desk away without success."Sam!"

"Cover Jamie!" Sam yells. Jamie continues to recite the spell and Sam keeps trying to get out from behind the desk. The two girls are sitting on the desk waiting. Bobby shoots at them. Andrew plunges a hand into Jamie's back. Jamie drops the bowl with spell ingredients.

"Dean!" Dean catches the bowl. "Fireplace!"

Dean throws the bowl in the fire, which turns blue. The ghosts all disappear. Jamie falls to the ground. "Jamie?" Sam pushes the desk away, freeing himself. The brothers help Jamie up. She nods, indicating she is okay.

Later that night Sam is asleep on the couch. Dean is asleep on the floor nearby with Jamie curled up beside him. Dean wakes up to find Castiel standing in the kitchen. Jamie opens her eyes and looks at Dean. Dean frowns. He checks on Sam, sees he is asleep, and walks over to join Castiel. Jamie gets up and follows him.

"Excellent job with the witnesses." Castiel tells them.

Jamie nods. "Thanks."

"You were hip to all this?" Dean asks.

"I was, uh, made aware."

Jamie crosses her arms and stares up at Castiel.

"Well, thanks a lot for the angelic assistance. You know, I almost got my heart ripped out of my chest."

"But you didn't."

"What about Jamie?"

"What about her?"

"Why didn't you protect her?"

"I-"

"He did. When it mattered." Jamie finally says.

"With AJ?"

"Yeah."

Dean turns back to Castiel. "What about back there? When he almost ripped your heart out? I thought angels were supposed to be guardians. Fluffy wings, halos - you know, Michael Landon. Not dicks."

Jamie sighs. "Dean."

"Read the Bible. Angels are warriors of God. I'm a soldier."

"Yeah? Then, why didn't you fight?"

"I'm not here to perch on your shoulder. We had larger concerns."

"Concerns? There were people getting torn to shreds down here! And, by the way, while all this is going on, where the hell is your boss, huh, if there is a God?"

"There's a God." Castiel tells him.

"I'm not convinced. 'Cause if there's a God, what the hell is he waiting for, huh? Genocide? Monsters roaming the earth? The freaking apocalypse? At what point does he lift a damn finger and help the poor bastards that are stuck down here?"

"The Lord works..."

"If you say "mysterious ways," so help me, I will kick your ass."

Jamie pushes Dean back. "So, was I right... about the witnesses?"

"Yes."

Dean looks at Jamie and then at Castiel. "This is some kind of a... sign of the apocalypse."

"That's why we're here. Big things afoot."

"God…" Jamie scoffs.

"Do I want to know what kind of things?"

"I sincerely doubt it, but you need to know. The rising of the witnesses is one of the 66 seals."

"Okay. I'm guessing that's not a show at Seaworld." He looks at Jamie.

Jamie sighs. "No, they are the seals written in the book of revelation."

Castiel nods. "Those seals are being broken by Lilith."

"She did the spell. She rose the witnesses."

"Mm-hmm. And not just here. 20 other hunters are dead."

Jamie sighs. "Including Dan?" Castiel nods. "That bitch."

Dean nods. "Of course. She picked victims that the hunters couldn't save so that they would barrel right after us."

Jamie turns back to Castiel. "And Andrew. How did she get a hunter? I salted and burned his body."

"Lilith is powerful, and she has a certain sense of humor."

"Well, we put those spirits back to rest."

Jamie shakes her head. "No. Don't you get it, Dean? It doesn't matter."

"The seal was broken." Castiel tells them.

"Why break the seal anyway?"

"You think of the seals as locks on a door."

"Okay. Last one opens and..." Dean trails off.

"Oh my god." Jamie grabs her head and falls against the wall.

Castiel looks at her and then at Dean. "Lucifer walks free."

"Lucifer? But I thought Lucifer was just a story they told at demon Sunday school. There's no such thing."

"Three days ago, you thought there was no such thing as me. Why do you think we're here walking among you now for the first time in 2,000 years?"

Dean looks at his sister. "To stop Lucifer." Jamie nods.

She looks at Castiel. "Can you? Stop Lucifer?"

"That's why we've arrived."

"Well... bang-up job so far. Stellar work with the witnesses. That's nice."

"Dean…"

"We tried. And there are other battles, other seals. Some we'll win, some we'll lose. This one we lost. Our numbers are not unlimited. Six of my brothers died in the field this week. You think the armies of Heaven should just follow you around? There's a bigger picture here. You should show me some respect. I dragged you out of Hell. I can throw you back in." Castiel vanishes, leaving Dean and Jamie alone in the kitchen. Later Dean wakes up. Sam is already awake and up and about. Jamie is sitting on the couch. Sam comes over with two cups and hands one to her. He sits next to her and looks at Dean.

"You all right? What's wrong, Dean?"

"So... You two got no problem believing in... God and Angels?"

Jamie shakes her head.

"No, not really." Sam says.

"So, I guess that means that you believe in the Devil."

Jamie eyes Dean.

"Why are you asking me all this?" Sam asks.

Jamie and Castiel are once again in the junkyard. Jamie closes the book she's been reading. "Vir bellator sum omni vita mea. Nunc necesse est assistant, patiendo, dum mundi patitur. Dum familia moritur."

"Te non electio." Castiel tells her softly, taking a step towards her. "Te sunt vocem. "

"I want to fight, Castiel. I was raised to fight."

"But you were born to see and to hear and to speak, not to fight." Jamie shakes her head and walks away from him. Castiel stares after her. "Si pugnare te mori." She stops and looks back at him.

"Ego mori."

Sam comes outside and sees Jamie standing by herself. "You okay? I heard Latin."

"I'm fine. I need to go, though."

"You have another job." Sam looks away.

"Sammy…"

"Hey, look. I got over you always leaving us a long time ago." He gives her a sad smile. She takes Ruby's knife out of the belt strapped around her hip and hands it to him.

Jamie moves her hair away from her face. "Sammy…when Dean was in hell we tried to make it work. We tried. And then…" A tear slips down her face as she looks away.

"Jamie." He wipes the tear away. "We had just lost Dean. You had just lost AJ."

"Sam, I'm so scared. What if Lilith breaks all the seals? What's going to happen then?"

Sam hugs her close. "I swear I will stop Lilith. I swear."