Sam can be heard screaming the background. Dean groans. "How long is this gonna go on?" He looks at Bobby.

Bobby looks at him. "Here, let me look it up in my demon-detox manual. Oh wait. No one ever wrote one. No telling how long it'll take. Hell, or if Sam will even live through it."

Jamie walks in and throws her keys down on the table. She gestures to a stack of papers she's carrying and looks at Bobby and Dean.

Jamie pours herself a drink and sits on the table. Bobby and Dean are looking through the papers Jamie brought.

"The news ain't good." Bobby gives Dean a pointed look.

Dean is reading. " 'Key West sees ten species go extinct'.

Jamie looks up. "Yep. Plus Alaska. Fifteen-man fishing crew all stricken blind, cause unknown. New York, teacher goes postal, locks the door, kills exactly sixty-six kids. All this in a single day. I looked them up. There's no doubt about it. They're all seals. Breaking. Fast."

"How many are left?" Dean asks.

Bobby looks up. "Who knows? Can't be many. Jamie you're a damn prophet, you tell us."

Jamie raises an eyebrow. "Not many."

"And where the hell are your angel pals?"

Jamie shakes her head. "You tell me." She finishes her drink and pours herself another.

"I'm just wondering."

Dean looks at him. "What?"

"The apocalypse being nigh and all...is now really the best time to be having this little domestic drama of ours?"

"What do you mean?"

"Well, I don't like this any more than you do, but Sam can kill demons. He's got a shot at stopping Armageddon."

Dean gets a look on his face. "So what? Sacrifice Sam's life, his soul, for the greater good? Is that what you're saying? Times are bad, so let's use Sam as a nuclear warhead?"

Jamie finishes her second drink. "It's a stupid idea, Bobby. "

"Look, I know you hate me for suggesting it. I hate me for suggesting it. I love that boy like a son. All I'm saying is maybe he's here right now instead of on the battlefield because we love him too much."

Dean and Jamie are in Bobby's salvage yard. Dean is looking up at the sky. "Castiel! Damnit, please."

Jamie hugs him. He looks at her. "Castiel!" Jamie yells. "Castiel, in nomine Dei egressus!"

Castiel appears. "Well, it's about time. I've been screaming myself hoarse out here for about two and a half hours now and all Jamie has to do is chant some damn Latin?"

"What do you want?"

"You can start with what the hell happened in Illinois."

Castiel tilts his head. "What do you mean?"

"Cut the crap. You were gonna tell me something."

"Well, nothing of import."

Dean can't believe this. "You got ass-reamed in heaven but it was not of importance?"

Castiel sighs. "Dean, I can't. I'm sorry."

Dean points at Jamie. "Then tell the damn prophetess over there, and she'll tell me."

"I'm sorry Dean, but I cannot reveal it to Jamie either. Get to the reason you really called me. It's about Sam, right?"

Jamie looks at Castiel. "Can he do it? Kill Lilith, stop the apocalypse?"

"Possibly, yes. But as you know, he'd have to take certain steps."

Dean sighs. "Crank up the hell-blood regimen."

"By a lot." Jamie adds.

"Consuming the amount of blood it would take to kill Lilith would change your brother forever. Most likely, he would become the next creature that you would feel compelled to kill. There's no reason this would have to come to pass, Dean. We believe it's you, Dean, not your brother and not your sister. The only question for us is whether you're willing to accept it. Stand up and accept your role. You are the one who will stop it."

Dean sighs, looking down. He take a moment and then looks up. "If I do this, Sammy doesn't have to?"

"If it gives you comfort to see it that way."

"God, you're a dick these days."

Jamie scoffs. "You don't know the half of it." She stares at Castiel.

Dean walks a few steps away and sighs. "Fine, I'm in."

"You give yourself over wholly to the service of God and his angels?"

"Yeah, exactly."

"Say it."

Dean looks at the angel. "I give myself over wholly to serve God and you guys."

Jamie turns to her brother. "You swear to follow his will and his word as swiftly and obediently as you did our own father's?"

"Yes, I swear. Now what?"

Jamie looks at Castiel. Castiel looks at Dean. "Now you wait, and we call on you when it's time."

"Bobby! Dean! Jamie! Help! Hey! Hey! Guys! Guys! Help! Dean!" Sam's screams are still sounding in the living room. Bobby, Dean, and Jamie are sitting at Bobby's desk. Jamie sighs deeply. Bobby turns to Dean. "Correct me if I'm wrong, but you willingly signed up to be the angels' bitch? He willingly did this?"
Jamie nods. Dean looks at him. "I'm sorry. You prefer 'sucker'? After everything you said about them, now you trust them?"

Dean gets up. "Come on, give me a little credit, Bobby. I've never trusted them less. I mean, they come on like shady politicians from planet Vulcan."

"Then why in the hell—"

"Because he has no choice, Bobby." Jamie tells him.

Dean nods. "Because what other option do I have? It's either trust the angels or let Sammy trust a demon?"

"I see your point." Bobby sighs.

It's oddly silent, and Jamie immediately picks up on it. "Dean."

Dean looks at her and then at Bobby. "You hear that?"

"Yeah, that's a little too much nothing."

Dean, Jamie, and Bobby hurry to the basement and open the window in the door. Sam is on the floor of the panic room, having a seizure. Jamie's eye widen in horror. Dean turns to Bobby. "What if he's faking?"

"You really think he would?" Bobby asks, looking at Dean.

"I think he'd do anything."

"Oh he's not faking…" Jamie mutters. Sam is slammed against the wall by an invisible force.

"Yeah, that ain't faking." Bobby agrees. They throw open the door and charge in to get Sam down and pin him to the cot. Jamie takes off her belt and sticks it in Sam's mouth.

"Oh Sammy…" Jamie mutters. Dean stares at Sam in shock.

"We're gonna have to tie him down for his own safety. Dean? You with me? Dean! Before he has another fit."

Dean snaps back to reality. "Yeah, yeah. Let's just get it over with."

Awhile later Sam, calm now, discovers he's been chained to the cot. He sits up. Dean is standing next to his bed. "We had to. The demon blood was flinging you all over the room. Tell me something, Sam. Why did you do this to yourself?"

Sam looks away. "You know why."

"Right. 'Kill Lilith'. The big excuse. But why? What, revenge? Right?"

"Of course."

"Revenge for what? For sending me to hell? Did you happen to notice I'm back? Alive and kicking. So what's the point?"

Sam looks at his brother. "Point? How about 'stop the damn apocalypse'?"

Sam is addressing an empty room, Dean is a hallucination. "My gig. Not yours. The angels said so, remember? God picked me, man. So you got any other fantastic excuses? Hmm?"

Jamie opens the door and walks inside. "Sam!" Sam doesn't see her. Jamie grabs unto Sam's shirt. "Come on Sammy. Come on." Jamie puts her hands on the side of Sam's head.

"I know why you really drink that blood, Sam." Dean tells him.

"Just leave me alone."

"Makes you feel strong. Invincible. A big bad wolf in a world of little pigs."

"No. You're wrong, Dean."

Jamie can now hear Dean. She glances in the direction where Sam sees him. "Sam, don't listen to him. Listen to me."

"It's more than that, isn't it? It's because your whole life, you felt different. Am I right?"

"Stop.'

"Oh, I hit a little close to home, huh? Not different because you were some lonely kid or because of your weirdo family."

"Stop it."

Jamie squeezes her eyes tighter. "Sam, it isn't really Dean."

"Because you're a monster."

"Shut up! Just—shut. The hell. Up." Sam yells.

Dean looks at him and smirks. "You know, normally they talk about how twins are just alike. But I think in this case, you're exact opposites. Jamie was always the innocent one, and that's why Dad sent her away. To protect her innocence, to keep you from corrupting her. You were always a monster. And you only feel right when you're sucking down more poison and more evil."

Sam rattles his chain. He shakes in Jamie's grip.

"Damnit!" Jamie yells opening her eyes. She holds Sam still. "Damnit Sammy."

"Monster, Sam. You're a monster."

"Dean, no."

Jamie closes her eyes again, putting her hands back on either side of Sam's head. "Let me in, Sam."

"And I tried so hard to pretend that we were brothers. That you weren't one of the filthy things that we hunt. But we're not even the same species. But I have to face facts. I've got a sibling to protect, and she isn't you. You're nothing to me."

Sam starts to sob. "Don't say that to me. Don't you say that to me."

Jamie growls. "Enough! Come back to me, Sam."

Sam looks around. He sees Jamie sitting beside him. Dean is gone. Sam tries to shove Jamie away. "He loves you more than me!"

"What? Sam snap out of it!" Jamie slaps him across the face. Sam realizes it hurts and looks up at her.

"Jamie?"

"Hi." She grips his hand.

"What are you doing in here?"

"Trying to help you."

Sam looks away. "Why? You hate me. You want me dead. You think it'd be better if I was."

Jamie stares at him. "Yeah. I thought that. But Sam…you're my brother."

"I betrayed you."

"Yeah you did. But it doesn't matter."

Tears stream down Sam's face. "I'm evil and worthless and a monster!"

Jamie wipes his cheek. "Sam, it's all in your head. All of it. It's your own guilt and the demon blood that is doing this to you. You've got to take back control, before it's too late."

"I don't know if I can." Jamie looks up. "What is it?"

Jamie looks back at him. "I'm being summoned."

"By the angels?"

"By Cas."

"What does he want?"

"I don't know. I'll be back as soon as I can." She wraps her arms around Sam. Sam closes his eyes and puts his chin on her shoulder.

"Jamie…" He starts to say.

"I know. I'm sorry, Sammy. I'm so sorry. And I forgive you." Jamie leaves.

The lighting changes: nightfall. The cuff on Sam's left arm snaps open, then his left ankle, then the other two. The door opens. Sam sits up, staring; he didn't do this. "Hello?" He gets up and slips out the door. "Someone here? Jamie?" He hurries quietly out of the basement without noticing Castiel behind the stairs. From a distance, the angel closes and locks the panic room door.

Castiel turns back to the river. Jamie walks up. She pulls her jacket tighter around herself as she walks up to him. "Castiel? What is going on?"

Castiel turns to her. "I'm sorry prophetess. I'm sorry you were put in the middle of this."

Jamie looks at him confused. "The middle of what?"

"You'll find out soon." Castiel puts two fingers on Jamie's forehead. She blinks and is standing in Bobby's kitchen.

"Dean?" Jamie rushes down the stairs. She sees the panic room empty save for Bobby and Dean.

Dean turns around. "Where the hell have you been?"

"With Cas, what the hell happened? How did Sam get free?"

Bobby sighs. "We're thinking Ruby."

"Ruby? No. She couldn't." Jamie closes her eyes.

Dean gets a determined look on his face. "Well, I'll tell you one thing. At this point I hope he's with Ruby."

"Why?" Bobby asks.

"'Cause killing her's the next item on my to-do list." Jamie opens her eyes. "Anything?"

Jamie shakes her head. "Whatever let him out is blocking my sight and there is enough demon blood left inside him to shield him from me. I don't know what happened. But you're right, I think he's going to Ruby."

Bobby looks at Dean. "I thought you were on call for angel duty, Dean."

"I am on call. In my car, on my way to murder the bitch." Dean goes to leave the room.

Jamie follows after him. "Wait for me."

"One thing." Bobby calls after them.

Dean stops and waits for Bobby to continue. "What?"

"Sam don't wanna be found, which means he's gonna be damn near impossible to find."

Dean scoffs. "Yeah, we'll see."

Jamie nods. "I got it covered."

Dean and Jamie are packing the Impala. Bobby comes out of the house. "Police found my car. Abandoned in an alley in Jamestown, North Dakota."

"He's switching up." Dean says.

Jamie nods turning to Bobby. "Any other cars stolen in Jamestown?"

"Two. 1999 Honda Civic, blue. Nice and anonymous, like Sam likes."

"What was the other one?"

"White oh-five Escalade with custom rims. It's a neon sign."

Dean nods. "You're right. He'd never take that."

Jamie looks at Dean. "Which is exactly what he did."

Bobby looks at the siblings. "You think?"

Dean nods again. "I know that kid. All right, Jamie and I'll head in that direction. You stay here, ride the police databases. We gotta find him quick."

Jamie goes over to the shot-gun side of the Impala. "Let's go."

Dean is driving, Jamie has his phone on speaker. "Cops found the Escalade in a ditch outside Elk River."

"How far away are we?"

"A couple of hours. I pulled up a weather map, made some calls. There's a town not far from there, Cold Spring. Lighting up with demon sign."

Jamie and Dean look at each other. "A good place to look."

"Hey, listen."

"What?" Dean asks, looking at the road.

"Us finding Sam? It's gotta be about getting him back, not pushing him away."

"Right." Jamie agrees.

"Right." Dean echos half-heartedly.

"I know you're mad. I understand. You got a right to be, but I'm just saying. Be good to him anyway. You gotta get through to him."

Dean grabs the phone and hangs up. Jamie looks at the phone and then at Dean. "Dean…he's still our brother."

Dean sighs.

Sam leaves the motel room. Dean and Jamie, hidden, watch him go, then enter the room. Ruby is still there; Dean attacks her. Jamie backs up. Sam reenters and defends her. "No. Let her go. Just take it easy."

Dean looks at Sam. "Well, it must've been some party you two had going, considering how hard you tried to keep us from crashing it. Well, solid try, but here we are."

Jamie moves towards Sam. "Yeah, here we are."

"Dean, Jamie, I'm glad you're here. Look. Let's just talk about this."

Jamie stares at her twin. "We're past talking."

Dean gestures to Ruby. "Soon as she's dead, we can talk all you want."

Sam nods to Ruby. "Ruby, get out of here."

"No, she's not going anywhere." Dean argues. Ruby makes her escape. Dean points at his sister. "Jamie!"

Jamie raises her hand but Sam grabs her arm and holds it behind her. Sam watches Ruby go. Jamie struggles in Sam's grip. "Get off me."

"She's poison, Sam."

Sam lets Jamie go. "It's not what you think, Dean."

"Look what she did to you. I mean, she up and vanishes weeks at a time, leaves you cracking out for another hit—"

"She was looking for Lilith."

"That's crap." Jamie spits.

Dean nods. "That is French for manipulating your ass ten ways from Sunday."

Sam sighs looking at his siblings. "You're wrong, guys."

"Sam, you're lying to yourself. I just want you to be okay. You would do the same for me. You know you would."

Jamie rolls her shoulders, trying to control her anger. "Sam please."

"Just listen." Sam raises his hand, realizes he's still holding Ruby's knife that he took from Dean, and tosses the knife on the bed. Jamie watches the knife and then looks at Sam. "Just listen for a second. We got a lead on a demon close to Lilith. Come with us. We'll do this together."

Dean stares at him. "That sounds great. As long as it's you, Jamie, and me. Demon bitch is a dealbreaker. You kiss her goodbye, we can go right now."

Jamie nods. "Yeah. She sits this one out, before Dean ganks her." Dean cracks a sarcastic smile at his little sister before they both turn back to Sam.

"I can't." Dean turns away, nodding. Jamie sighs looking between her brothers. "I need her to help me kill Lilith. I know you can't wrap your head around it, but maybe one day you'll understand. I'm the only one who can do this."

Dean turns back around. "No, you're not the one who's gonna do this."

Jamie steps between them.

"Right, that's right, I forgot. The angels think it's you." Sam's tone is almost mocking.

Dean challenges him. "You don't think I can?"

"No. You can't. You're not strong enough."

Dean takes a step towards Sam. "And who the hell are you?"

"Dean." Jamie puts a hand on his chest.

"I'm being practical here. I'm doing what needs to be done."

Jamie looks back at her twin. "Sam." She puts a hand on his chest.

Dean stares hard at his brother. "Yeah? You're not gonna do a single damn thing."

"Stop bossing me around, Dean. Look. My whole life, you take the wheel, you call the shots, and I trust you because you are my brother. Now I'm asking you, for once, trust me."

Jamie sighs, her eyes shifting between her older brother and her twin. "Let's all calm down, okay?"

Dean looks at her and then immediately back at Sam. "No. You don't know what you're doing, Sam."

"Yes, I do."

Dean seeths. "Then that's worse."

Sam stares at him. "Why? Look, I'm telling you—"

"Because it's not something that you're doing, it's what you are! It means—" Dean cuts himself off. Jamie looks over at Dean shocked.

"What? No. Say it." Sam has tears in his eyes. Jamie looks at Sam, unsure which brother to go to.

Dean looks straight at him. "It means you're a monster."

Sam nods. Jamie's mouth falls open. A tear falls from Dean's eye; SAM doesn't see it before he pushes Jamie backward and punches Dean. Jamie falls to the floor. Dean goes down hard, then gets back up and watches Sam for a moment before punching back. Jamie gets up and grabs unto Sam. Sam shoves her away. Sam and Dean fight, Sam dominating. Anything in the room that can break does. Jamie grabs unto Dean and Dean pushes her back. Sam throws Dean through the glass door. Dean hits the floor and doesn't get up. SAM pins him down, choking him, Jamie grabs his arm trying to get him off of Dean. Sam shoves her back and she cuts her hand on the glass as she goes down.

"Ow. Damnit!" Sam lets go of Dean and then looks over at her. "Sam…" Jamie drops down beside Dean.

Sam looks down at her and then at Dean. "You don't know me. You never did. And you never will." He walks away.

"Sam, don't go!" Jamie pleads.

"You walk out that door, don't you ever come back." Dean tells him. Sam stops at the door and turns back, then leaves. Jamie holds her bleeding hand against her chest.