Mary was gone.

She'd been dead for years but now her soul was freed from the house they'd once lived in. Sam and Dean had handled that.

Missouri exhaled as she poured John some tea. She'd just finished scolding him for not talking to his sons.
"What about when you die of a bad heart, hm? Who tells them?" Missouri finally asked. John jerked his head up and stared.
"How'd you know...oh. Right." He looked back down.
"Actually I know that because my twin sister told me." Missouri replied.
"Your twin sister?" John looked up.
"Adele. She married Doctor Webber, the Chief of Surgery at Seattle Grace. Because she was stuck with me in childhood she knows about our side of reality." Missouri sighed. "There is help for you, if you don't become a lone wolf."
"I'll keep that in mind."
"Besides, that blonde intern is going to be keeping an eye on you." Missouri added.
"Blonde intern...you mean Dr. Stevens?" John looked up. Missouri laughed a bit and leaned back.
"You've been trying to avoid thinking about her. You think you should focus on the memory of your wife. But if she is a natural like you seem to think..." The psychic laughed. "You should train her."
"She got lucky!"
"She got the ghosts to calm down." Missouri exhaled. "You should get back to the hospital soon. Or at least get to Seattle."
"I can't yet." He stated. "My sons need some help. still."
"But what about your heart?"
"When I can't go anymore..." John stood up, "I'll go back to Seattle Grace."
"And you'll get chewed out."
"...Izzie gets to distracted by me. By my side of the world." John stated. "I can't let her get involved."
"I thought she was was Doctor Stevens."

John exhaled and faced Missouri.
"What are you suggesting if I go back?"
"Taking her on."
"She's younger then Dean!" John exclaimed.
"As an apprentice." Missouri clarified.
"Really? I kind of already have a legacy."
"You have your sons. Izzie has her own view of the world. She'd be a different hunter."
"I'll think about it."

John exhaled as he walked back to his truck. He hadn't been back to Seattle for a while. Chances were Izzie had forgotten everything. None the less he found himself dialing a number he called a lot.
"Hey Bobby. I need to talk. Can we meet up...?"