2.) She enjoys hanging out with Maito Gai. While he is an extraordinary oddball, he is perhaps the most rock-solid secret keeper in all of Konoha. And, despite his dislike of all things alcohol, he is a man who can hold his own in the face of booze very, very well. And, once she looked beyond the garish spandex suit and the odd behaviour, she saw that Maito Gai truly was everyone's friend. Even hers.
3.) Despite what her pink-haired apprentice likes to think, her strength is natural. While her entire family is strong, she is a freak of nature, the first-born of a bloodline she will forever deny to the world. She knows the gift is hereditary, but then, she admits that she's too old, too bitter and too jaded to bear some sprogs.
4.) Tonton is her personal experiment, the first, last and only time she gave in to the burning desire as a scientist, gave in to the very aspect of her craft that let her see the world through Orochimaru's eyes for a few, fleeting moments. The result of it was threefold: First, Tonton is an extraordinarily long-lived, resilient and smart piglet, second, she understands Orochimaru's unholy fascination with things Man Was Not Meant To Dabble With, third, she has destroyed every single and last note about the process involved and has sworn, once again, to destroy everything Orochimaru does in this regard.
5.) She did not feel betrayed when Orochimaru left the Leaf, leaving behind atrocious experiments and the shattered shells of humans. No, he had betrayed her far, far worse when he all but mocked her for the death of Nawaki. Her, she who had stood by his side when they avenged his family. It is because of this that she resents Orochimaru even after decades. Loyalty is one thing, but family is ten times as important. Too bad hers is dead.
6.) She is responsible for Shizune ending up in a great number of embarrassing situations. Because the girl - woman, now - never had the benefits of an intrusive, annoying bastard and an arrogant, ruthless bastard of a teammate to harden her to the realities of what men really are, she decided to take matters into her own hands. These days, Shizune is pretty adept at navigating through cities, half-drunk and naked without getting spotted.
7.) Ironically enough, she was good friends with Hoshigaki Kisame until the sword-bearer decided to come after Naruto again. Their shared love for booze, play and debauchery - and their similar background of blood and murder - saw one of the most unlikely friendships in the world of shinobi gambling prosper. The fact that he wasn't afraid of her stone-rending strength and that she could shred him even with his precious chakra-devouring blade at hand helped a lot... after all, respect is easier to give and gain between equals than between superior and servant.
8.) She is the only person to win a drinking contest against Orochimaru, ever. If only because her pale-faced oddball of a teammate had just come back from a mission, all but out of chakra and dead tired. She considers this her greatest victory against him, because no matter what one can say about Orochimaru, he can hold his booze better than just about anyone.
9.) She is the first Hokage, ever, to realize that a shadow Clone can do the annoying paperwork just as well as the real deal, and the subsequent joyful drinking binge lasted just about long enough for her chakra control to slip and the memories of hours of tireless paperwork signing rushing back into her brain. Ever since then, she has abstained from alcohol during the hours of chakra-made slave work.
10.) Tsunade is the first and only person, ever, to manage to out-eat Naruto in a ramen-eating contest. His demonically enhanced metabolism doesn't hold a candle to the finest and most perfectly controlled body in the world, after all, and even though she doesn't touch ramen for three years after that, the face Naruto made when he realized he lost is truly a precious memory.
11.) While she loathes the paperwork that comes with her office, she is the only Hokage in the history of the leaf to leave none behind when she dies. If she'd known that, of course, she would've slacked off for a few weeks... after all, if she had to worm her way through a backlog of a few months worth of paperwork, her successor should have had to do so, too.
12.) She is a master cook. She knows every 'Secret Recipe' of the Fire Nation and most of those from abroad. She has prepared everything from a classic Earth Nation Stick-With-Pig to the most exotic fish dishes of the Water Nation. She is less proud to admit that she did most of that to kill people with poison, though, and delights in those rare few moments she can indulge in this most unlikely of hobbies.
13.) She can - and has - slept in every environment the Elemental Countries have to offer. From the heavy rainstorms of Rain Country to the abyssal volcanic clefts of the westernmost reaches of the Earth Nation, from between taking shelter in the artificially created wave-breakers of Hidden Mist to the highest treetops of the Land of Bears, she has been there and invariably spent at least a night - or, in some cases, day - there. But, loath to admit as she is, there is no place like Konoha.
14.) She was the arsonist of their team. While Orochimaru occupied whatever guards tried to stop them and while Jiraiya was trying to clear his head from the hangover, she had set up the incineration charges, prepared a few experimental liquid-based explosives and generally changed the status of whatever room the team was in at the time from 'Safely Habitable' to 'Would you like to be fried in that?'.
15.) Shizune learned to fear hot springs and remote inns. She has no idea how Tsunade does it, but since she inevitably ends up in a myriad of horribly awkward situations at these locations only, she knows it's the doing of her master. If she realized that this is because Tsunade tries to have her find a man before it's too late, before poor little Shizune is too settled in her ninja ways to stop. Alas, it is another wish Tsunade will never see to come true. A pity, really.
16.) Tsunade has escaped from some of the most vicious predators in the known world. She managed to outrun a pack of Four-Fang Flayers during her last visit in the Land of Lightning, she managed to get away from one of the great white sharks of the Mist - she is among the six people in the world to ever do so - but most importantly she has evaded the most ferocious beast of all for years on end. Tsunade has escaped her debtors for years, and it's unlikely that they'll ever catch up. Even if she sits still in a village full of heavily armed murderers at her command. Especially if she sits still in a village full of heavily armed murderers at her command.
17.) She has managed to get Hatake Kakashi to show up on time when he is called. Everyone suspects that she threatened him with bodily harm, that she threatened to set his Icha Icha on fire or that she used some other horror as leverage against him. Nothing like this happened. She merely told him that if he didn't Sakura would take over his next urology examination and left it at that. Ever since then and just for her, Kakashi comes when he is summoned.
18.) She reacts unfavorably to certain songs being sung in her presence. No-one really understands why - after all, for their kind of song, the one you bellow along with loudly when you're drunk as hell, these songs are pretty tame - but no-one asks her about it either. If they knew that it was her - her and her team - that made these select few songs they would understand. But it's another secret that'll die with the four of them.
19.) Since her arrival in Konoha, she has refereed thirty-nine 'duels' between Gai and Kakashi, has saved Shikamaru from his mother twenty-seven times, thrown some idiot out of the window twenty-one times and has taught Sakura eighteen new jutsu. But she has visited Naruto in his home only twice, and she cherishes these moments all the more for their rarity.
20.) She helped out a lot with adding her own face to the Hokage Monument. Not out of pride, ambition or something like that, no, because she realized that the people - her people - needed a symbol, a rallying flag in the turbulent times that their village would be going through. Her ability to cleave rock like ordinary men did with cardboard came in handy, too.
21.) Tsunade dies in a way she never expected, from old age. Surrounded by her successor and his family, by her friends and his friends and their friends. The eternally young grandmother of the Leaf dies happy, knowing that her legacy - and her name, too - will live on for a long, long time.
I disavow all knowledge of what has been revealed about Jiraiya. I will continue to picture him as a strange, if honorable man, not someone who abandons his godson to the wolves. (If you do not understand why this is so bad, consider that 'godson' makes Naruto /family/ to Jiraiya in a feudal Japanese setting such as Naruto).