Four turtles, four brothers named after the four Renaissance artists lived in the sewers of New York with Splinter, a rat whom they called father. Years had passed after they eliminated Shredder whose identity was Oroku Saki leading the notorious Foot Clan, they managed to make peace with Karai, Shredder's adopted daughter who left the Foot Clan.

One year had passed since the wedding of April O'Neil and Casey Jones, the turtles and Splinter lived in peace. Recently April got a job in an organization Vital Situation Swift Elimination (VSSE).

One day, it was supposed to be a normal day for the turtles: Leonardo wearing a blue mask was meditating, Raphael wearing a red mask was working out with dumbbells, Donatello wearing a purple mask and glasses was keeping technology up to date, and Michelangelo wearing an orange mask was playing video games. The turtles received a call from April.

"Hi April, how are you doing? How's your job at the VSSE?" Donatello asked.

"Hi Don, I'm doing fine and it's going well at the VSSE. I have some bad news for you," said April.

"Tell us."

"The Foot Clan is being acquired by the organization Kantaris," she showed him the insignia of the other organization.

"What do you know about Kantaris?"

"Their leader was also being called Kantaris and there's no other information about her. The organization is known to be an arms supplier to the black market," April showed him the photo of a grey-haired woman in her mid-30's.

"What's at stake for us?"

"I need you four to infiltrate their base which is a hotel covering their weapons factory. Good luck and be careful guys," April ended her call.

Donatello informed the others and Raphael responded, "The Foot, I thought they're history."

"You're telling us that the Foot is being acquired by an arms supplier?" Leonardo asked.

"It's true, April told us to infiltrate their base," Donatello spoke as he provided his brothers the location.

"I have a bad feeling about this," Michelangelo muttered.

"The Foot might become stronger under Kantaris' leadership and it's up to us to find out," said Leonardo.

"Proceed with caution my sons," Splinter reminded them.

Leonardo took his twin katana, Donatello strapped in his bo staff, Raphael had his twin sai ready, and Michelangelo equipped himself with twin nunchaku. The four brothers set out to the Kantaris base.