Pain
"Elaine, are you sure you are all right?" Guybrush asked, seeing his wife still awake. "What are you thinking about? Is it still about us? I told you I regret nothing from our past."
"You died Guybrush," Elaine told him. "It was my fault. I should have lost you forever. Even if you don't regret it, I do."
"But you didn't." Guybrush reminded her, "My death was not your fault. I am going to make the most of this second chance, or third chance. Or whatever chance I am up to."
"Almost losing you hurt, so much. I love you."