There are many different ways to begin a conversation. "I've decided to fall in love with you" is, technically, a work of grammatical brilliance, and therefore a viable option.
Of course, Wilson doesn't know a work of grammatical brilliance with which to rebut this conversation-beginner, so he settles for "Whuh?"
House grins. "Yup. I'm really bad at chicks, and you're really good at them but in a way that pisses me off, so I've decided that they can all go screw Chase if they want and I'm going to fall in love with you."
Wilson is silent for a long time. House just sits in his chair, twirling his cane between his fingers and smiling like Buddha. Finally, Wilson manages, "You can't just make yourself love someone."
"Then why did His Almightiness make me awesome at everything else?" House asks immediately.
Wilson runs his hands through his hair. "It isn't real love if you force it…"
"Define real love, then. I'll meet your criteria on this."
Very, very quietly: "It's not real if you have to force it, you idiot." Out loud, Wilson says, "I'm leaving."
When he is far down the hall, House leans out of his door and yells for all the world to hear, "Hey, I'm making an effort here! Get your ass in gear and love me back already!"
Wilson just keeps going.
House pouts. Obviously, he's going to need a new plan of attack.