A/N: This is a Grey's Anatomy/Twilight crossover set at Seattle Grace Mercy West Hospital. In my story Izzie and George are still in it!

Here are the couples:

Meredith and Derek

Izzie and Alex

Callie and Arizona

Mark and Lexie

Owen and Christina

Chapter One: A New Beginning

Meredith POV:

"Seriously?" I asked Christina.

"Seriously!" She responded. We both laughed. She was telling me that some drunken guy hit on her at Joe's and Owen almost killed him.

Izzie walked up to both of us. She looked pretty ticked off. "Okay Mer, you know I love you and I love your husband and everything but—" I cut her off.

"Clinic again?" I asked.

"Yes! This is the second time this week! Make George do it or something! Or better yet that new guy who's coming in today." She said to me. I completely forgot about the new doctor that Derek was telling me all about for the last month. His name was Carlisle or something strange like that.

"Iz, you cannot make Dr. Carlisle Cullen do such work! He is one of the best in whole wide world!" Christina said astonished.

"Hmm… Well he can't be as great as Mer's mom considering I've never heard of him." Izzie replied. The only reason that I had ever heard of Dr. Cullen was because Derek hadn't shut up about him ever since he found out that he was coming to our hospital.

"Seriously?" Chris said.

"Oh no not another of your 'seriously' talks!" George said as he was approaching the nurses' station where we were all standing.

"Hey George" Izzie said to him. He returned a 'hello' to her as well. We all started talking like what normal best friends do until a new intern walked up to us.

"Umm hi, which one of you is Dr. Shepherd?" She asked. She must have gotten George mixed up with Derek… well somehow. Or maybe she's referring to me. Technically Derek and I are 'Post-It' married but no one has ever called me Dr. Shepherd or anything like that before.

"Excuse me?" George asked.

"Well Chief Shepherd told me to go get his wife since his pager is like broken." The new intern has a sweet and innocent smile much like my sister's. I wonder where Lexie is now that I think about it…

"Oh uhh yeah that's me. Sorry it's just that I'm Dr. Grey and no one has ever called me Dr. Shepherd." I apologized to the confused intern. I'll explain the whole situation about Derek and me later.

"Oh I am really sorry Dr. Grey. You see it's my first day here, and I'm still trying to know everybody's name and everything." I felt bad for her as she was scared out of her mind. I bet Christina is glaring her down or something.

"Hey, it's no problem. It's totally fine. So where is my husband?" I asked.

"He's in his office with Dr. Cullen. He wants you to meet him."

"He's speaking with Cullen?" Christina interrupted.

"Umm yeah he is…" The new intern seemed to already be afraid of Christina, well that was no surprise… Chris could be a well… a terrifying person. She means well but she's… intense.

"Okay thanks for the info… I'm sorry I don't know you name." I said.

"Oh I'm sorry I never introduced myself yet. My name is Amy Trait." She said.

"It's nice to meet you. Who's your resident?" I asked.

"Dr. Yang." She replied. I could see an evil smile creeping upon Christina's face. Oh great.

"Well I gotta go…" Izzie said pulling George along with her.

"Yeah me too." George said.

"Duty calls" I said walking away from the scared intern and her teacher.

I walked down the florescent hallway down into Derek's office. I knocked once before entering like I always did. He always told me that I never had to knock but I always did. Force of habit I guess. As I entered his office I saw Derek talking with Dr. Cullen.

Derek turned to me and said "Oh here is my wife Meredith. Mer, I want you to meet Dr. Cullen."

"It's a pleasure to meet you Doctor. I can't wait to work with you." I said extending my hand to shake it. He shook my hand. His hand was ice cold. I tried not to show any expression.

"It's a pleasure to meet you Dr. Shepherd." He returned with a smile. Derek was about to correct him until he saw my face. Even though by law we are not married, I like being called Dr. Shepherd. Derek promised me a real wedding sooner or later.

"So Mer, Dr. Cullen here is going to be following you around today, shadowing you and getting a feel of how everything works around here. Is that okay?" Derek asked.

"Yeah that's fine. I'd be glad to." I was so mesmerized by his perfect face, smile and eyes. He needs a 'Mc' name. Hmm, what could he be…?

"Oh and Mer I need you to page Yang, Karev, Sloan, Stevens, O'Malley, Hunt, Torres, Robbins, Bailey, Webber, Kepner, Avery and Little Grey and tell them to get in here, I want them to meet Dr. Cullen." He instructed me. I nodded.

"Yes sir." I said. He smiled. He loved it when I ever I called him chief or Sir.

He then turned to Cullen. "You see we have a little family here at Seattle Grace Mercy West."

"Oh how nice. At Forks, we never had that. I only had my own family at home. But it's nice that you have your own little family here." Dr. Cullen said.

"Oh so do you have a wife or kids?" Derek asked.

"Yes I have a beautiful wife, just like yours." I blushed. They both saw me blush.

"Well it's true Mer." Derek said, and then let Cullen continue.

"And I have five kids." Cullen said like it was the norm.

"Wow five kids that must be entertaining." Derek said to him.

"Well we adopted them all. My wife Esme and I started adopting five years ago. We were both 28 at the time. Edward was our first; he was twelve at the time. Then we adopted Alice when she was thirteen. Esme and I were 30 at the time. Then just last year when Esme and I were 32 we adopted Emmett. Rosalie and Jasper came to us when Esme and I were about 25. They were my sister's kids and her and her husband died in a car accident." Cullen finished.

"Oh I'm really sorry to hear about your sister and her husband." Derek said sincerely to him.

"It's okay, thanks."

"So how old are all your kids." Derek asked.

"Well Emmett is eighteen, along with Rosalie and Jasper. Edward is seventeen and Alice is sixteen, well almost seventeen. Emmett, Rose and Jasper are all seniors and Edward and Alice are both juniors. What's so nice about having all of them is that they are each other's best friends. They do everything together. Even make a mess together." Carlisle chuckled.

Christina bursted through the doors of Derek's office. Derek turned to her. "Yang were you waiting by the door or did you just sprint to my office?" Derek asked.

"Shut up you!" She hissed at Derek. The she turned to Dr. Cullen. "Hi I'm Christina Yang, and I am a big fan you yours!" Christina went on and on and Dr. Cullen pretended to be interested in what she had to say. Soon after everyone else filed into Derek's rather large office, they were all greeting Dr. Cullen.

"Hey, what do you say, we all go to Joe's tonight to welcome Dr. Cullen to Seattle." Mark offered. We all agreed since we all did love Joe's.

"Hey and also invite your wife too." Derek added.

Normal POV:

Mark and Lexie arrived at Joe's first. They both sat down at the bar and waited for Joe to walk over to get them their usual. Mark had been wanting to ask Lexie something for a while now, so he figured that now would be the perfect time for it. Soon Joe walked over with Lexie's Coors Light and Mark's Budweiser. Lexie took a sip of her beer, as Mark blurted, "I think we should have a kid."

Lexie nearly spit out her beer. "Umm, what?"

"I think that you would make an excellent mother. Besides I'm almost forty and I'm getting older and older every day." Mark explained smiling. Lexie was still in shock.

"Mark I'm only twenty-nine though! And no I would not make an excellent mother! I would like freak out!" Lexie did want a baby; Mark's baby but not now. She was still so young.

"Uhh Lex, twenty-nine is not all that young you know. Lexie, you still have more time in all but… I don't. I want to be a father and I want to have your babies." Mark said sincerely

"But Mark I mean, we aren't even married yet! Shouldn't we get married and then start a family?" Lexie asked. She was still in shock at Mark's question.

"Trust me Lex; you'll be getting that ring soon." Mark said. Just as he was saying that to Lexie Meredith and Derek walked in. Mark spun around in his stool to face them. He then stood up and gave Meredith a kiss on the cheek. Lexie was still in complete shock.

"What wrong with you? You like you just saw a ghost." Meredith said to Lexie.

Lexie swallowed hard then shook her head. "No—I'm uhh fine, just fine."

Mark was smiling ear to ear. Derek noticed but ignored it. Just then Owen and Christina walked into Joe's along with Callie and Arizona.

"Hey guys." Owen said to them.

"Where are Izzie and Karev?" Callie asked.

"Yeah why didn't they just car pool with you guys, I mean you all live together… Be energy efficient like us!" Arizona said as she gave the girls a round of high fives.

"I hate living with all girls…" Owen muttered.

"I hear ya." Mark said to Owen.

"What are you talking about? Karev and I live with you too." Derek interjected.

"My point exactly." Mark said. Derek playfully punched Mark in the arm.

"Only the first round is free this time guys." Joe said as he approached us. They all laughed at that. Last time when the gang were all here together they must have costed Joe about two hundred dollars. Joe handed out the usual drinks as they all walked over to a few high tables and pushed them together. Joe pretty much let them do whatever they wanted, it was his bar. When Joe went to hand Meredith her Normal Mike's Hard Lemonade she declined and looked at Derek. They both looked at each other. She told Joe just to give her water. They all sat down and started to talk. George and his girlfriend Kim walked into the bar and took a seat next to them.

"As I live and breathe, Mr. George O'Malley!" Mark said sarcastically.

"Sorry we're late. Can I blame it on traffic?"

"O'Malley seriously? There was like no traffic!" Derek said and everyone started laughing saying 'Typical O'Malley…'

Jackson walked into Joe's with his girlfriend Mary. "You're late Dr. Avery! I could have kicked you off of brain surgery tomorrow…" Derek tried to say in all seriousness, but failed.

"Oh-no Chief Shepherd! Please don't I beg of you!" Jackson said with a girly voice. Mary stood behind Jackson. Kim and Mary were pretty shy people. Everyone continued to talk like best friends would. About five minutes later Karev and Izzie walked into Joes.

"Have no fear Karev is here!" Alex said jokingly.

"Karev you sound like a five year old." George said to him.

"Yeah Alex, you know I love you but please don't ever do that again." Iz said to him. Izzie sat down next to Christina and Meredith.

"Okay now that everyone is here let's make a toast like we always do!" Derek started, but then Owen cut him off.

"Uhh Der, you remember the reason we all went out was to get to know Cullen…"

"Oh right… well, we go out every week so it's not like it's out of the ordinary…" Derek said. Meredith looked at him and smiled.

"Okay enough of the whole 'silent talks' between you too!" Christina said.

"Well they are twenty minutes late… so I say if they aren't here in ten minutes we start the toast without them." Arizona announced, and everyone agreed.

"Okay we need to play a game!" Mark said. They all looked at him for an answer to his own statement. "Okay does anybody know any?" No one said a word.

"Well I mean what's that game that you play with your niece Mer?" Izzie asked.

"The initial game where you say someone's initials and you try to guess it?" Meredith asked.

"Yes that one! Let's play that one!" Most adults would find this game to be extremely stupid, let alone not having the intense knowledge that the doctors had. But no, not the Seattle Grace Doctors. When they played any game, they got really into it.

"Okay I'll go first!" Mark started. "Hmm… okay A.W."

"Famous?" Callie asked.

"No."

"Male?" Arizona asked.

"Nope not a male."

"Female?" Jackson asked. They all turned to Jackson.

"How in God's name did you graduate Med. School?" Derek said. They all started to laugh. "It's just another reason that I can kick you off tomorrow's brain surgery!"

"Okay that was a valid question. It could be a Lady Gaga!" Jackson said. They continued to play that round until Own guessed Adele Webber. Then Owen went.

"Okay… let me think… Ohh I got one! N.J. Have fun with this one!"

They all started to guess. They finally knew that it was a Jonas but they couldn't figure out the names of any of them. They all started to guess any 'N' names. It was starting to get rowdy trying to think of one. And then Carlisle and Esme walked in. They barely noticed him at first.

"Umm guys…" Meredith started to say. She looked at Carlisle and his wife who were both standing there awkwardly. All of the doctors looked at Cullen and his wife. They didn't blush, in fact they had no shame at all that they were playing a kids game.

"Oh hey Dr. Cullen. And you must me Mrs. Cullen. It's a pleasure to meet you. I've heard so many great things about you." Derek said like a complete gentleman.

"Outside of the hospital I am just Carlisle and yes this is my wife Esme." They all gazed at Esme's beauty. They were both similarly pale and had the same golden eyes. Her hair was soft caramel curls that fell to the upper-middle of her back. All of the Seattle Grace doctors introduced themselves by their first names.

"Wow out of all of Carlisle's doctor friends you guys are probably the friendliest." Esme said.

"Well I guess that's what you get when a slutty intern dates an attending" Karev started and looked at Lexie and Meredith who both blushed and laughed. "And you start to date your best friend." Karev looked at Izzie. Callie and Arizona looked at each other as well. "And you turn out to save someone's life…" They all turned to Jackson, George and Christina. "And finally when you are like dirt poor from Med. School, so you have to live with them."

"Wow, that's quite a few connections there!" Esme said.

"Most of them are true but I was not the slutty intern!" Meredith tried to defend herself.

"Yes you are but I still love you." Derek said.

"Okay Derek Shepherd I wasn't the one who got me drunk!"

"Your right" Derek started, "Joe did."

"Joe did what?" Joe asked as he was approaching their table to as Carlisle and Esme what they wanted to drink.

"You served Der and Mer way too much alcohol." Izzie said.

"You'd be surprised at how booze can bring people together…" Joe said. He turned to Carlisle and Esme and asked them what they wanted to drink.

"Miller Lite for me and a ginger ale for the lady." Carlisle said.

"Wow that's so sweet how you ordered for her… Derek why don't you ever order for me?" Meredith asked.

"You change your mind every time we ever go out!" Derek explained. Meredith physiologically put a hand on her stomach but then took it for in an instant when she figured out what she was doing.

"Oh My God!" Cristina said.

"What?" Owen asked we all looked at Christina who was looking at Meredith and then at Derek.

"You… you're… you guys… Oh my God I need a drink!" Christina said.

"What is your problem?" Callie asked.

"Christina!" Meredith said. "How did you… how could you know?"

"Wait what is going on here!" Mark said.

"Why don't you too tell them…" Christina urged. Meredith and Derek both stood up. Derek walked around to Meredith's side of the table and put his arm around her waist. He looked at her urging her to tell them the news.

"Umm… well we weren't really planning on saying anything tonight but since someone figured it out…" Meredith glared at Christina who looked quite pleased with herself " Umm me and Derek are umm expecting…" Meredith said.

".God… I'm gonna be an aunt? A real aunt?" Lexie said.

Everyone was freaking out that Meredith was going to be a mom. In all of this time of happiness it was Karev who asked the un-thinkable. "What are you going to do about your job?"

"Umm…" Meredith mumbled.

Meredith POV:

Why the heck did Alex have to ask that?

"Umm I don't know yet…" I mumbled. I was starting to get discouraged, but my McDreamy was looking down at me with those beautiful eyes.

"We'll figure it all out when the time comes." Derek said to Karev. Izzie moved to where Derek was sitting so Derek and I could sit down next to each other. I looked over at Lexie. I could tell that something was wrong with her, I could just tell. She looked excited to be an aunt in all but it's not Lexie excited. I needed to figure out what was wrong with her.

"Hey Derek, I need you to find out what's making Lexie just not herself, so I need you to talk to Mark. I mean just look at Lexie. She looks like she could burst into tears at any second. And it's not just because I told her about the news. It was before then." I whispered to Derek. He looked at Lexie who looked shaken up and then he looked at Mark who couldn't be happier. "And Derek I swear to God, if he did anything to hurt Lex I give you full permission to punch him again." I added in.

"Okay, I'll do that since he wouldn't listen to me the first time that I punched him. Apparently he still went for it." Derek whispered back to me.

"Hey Lex, I need to talk to you." I said to Lexie.

"Umm okay." Lexie said as we both stood up and walked over to the bar. I saw out of the corner of my eye Derek and Mark going to the other side of the bar.

"What's wrong with you?" I asked her.

"Nothing." Lexie replied.

"What do you mean nothing? Lex, you should see your face. Something is obviously bothering you!" I almost yelled.

"Mark wants a baby!" She blurted.

"Holy Crap! Umm uhh… well wait; I don't see the problem…" I said. "Lexie, you had a great childhood. I didn't. If anyone should be nervous about a baby it's me. I mean you had that mother and father, me I just barley had a mother and my father was too busy being your father." I hated to think about Thatcher, but I sort of had to a lot since he has one of my kidneys.

"MEREDITH WE AREN'T EVEN MARRIED!" Lexie yelled which got the whole bar's attention.

I could hear Christina laughing at Lexie's outburst.

Lexie walked back to the table without saying another word. I could tell that she was confused and scared. I followed her back and sat back down with everyone. A minute or so later Derek came back with Mark. Mark looked like he couldn't contain his happiness while Derek was semi-smiling.

"We'll talk about it all when we get in the car…" Derek said to me. I agreed.

The rest of the night was enjoyable. We all talked, like every time we came here. At around ten-thirty we all decided to go home and get some sleep for tomorrow, since we all had pretty early shifts at the hospital.