5 years after the events of Season 10 of The Blacklist, the Task Force under the Post Office has disbanded. Everyone has gone their separate ways and some, like Harold Cooper have even retired. But soon, the news lights up with an other-dimensional portal opening and bringing in corrupted creatures, gods, demons, and warriors from this strange world. Aram Mojtabai quickly ID'd them as champions from a popular game known as League of Legends. As soon as the ID came through, the families of the Task Force were attacked and killed. Only the members survived. It wasn't long before the government of the United States called them into action. Now Reddington, Ressler, Navabi, Cooper and Mojtabai must return to the Post Office and defeat the champions from another world that threaten the existence of humanity.