Pain
She can think of no greater pain than what her daughter-in-law and her brothers have been through.
True enough that there are a number of orphans in all the shinobi villages simply due to the wars and missions. It's not uncommon for children to grow up without one or both parents.
But to have their mother deliberately sacrificed like that is simply chilling.
Shikaku teases and calls her an old mother hen.
She scoffs right back and asks if there's something wrong with that.
She can't help it, it's in her nature.
And her husband wouldn't have it any other way.
