"Doctor Isles we have the results back from those blood tests you requested" the young laboratory technician advises. Maura looks up from her microscope as the young man approaches. Maura's been focused on the chemical elements and she's tried using every approach she can, to find more clues.

"Oh thank you" Maura says as she takes the file. She scans the reports and sees something that sets off an alarm bell. Jane has higher than normal amounts of Ibuprofen in her system. It's not life threatening and it's not as high as the victims Lilly and Maria but it is still unusual. As she thinks it through, she realises there is probably Ibuprofen in the treatment from Doctor Hughes. She picks up the phone and calls Suzie.

Senior Criminologist Chang arrives as requested. "Suzie would you recall the blood sample from this analysis and run the blood for the chemical elements we've been investigating please" Maura asks. Suzie nods and takes the reports from Maura. "Suzie, would you mind keeping any findings confidential for now. Come directly to me when you have anything."

"Of course Dr. Isles" Suzie reassures Maura.

Maura looks at her watch; it's nearly lunchtime. She decides to head home to see how Jane is going. When she arrives home she's surprised to find neither Angela nor Jane are there. The place doesn't look to have been disturbed. Maura then notices a cup of tea on her dining table. When she takes a closer look she can see it hasn't been touched. She touches to cup and finds it cold. That's odd Maura thinks. Maura calls Doctor Hughes. He advises he hasn't called on Jane yet. Maura starts to get anxious; she can't reach Jane or Angela on their cell phones. She calls the hospital to see if Jane's been checked in. She hasn't

Maura calls Frankie, who hasn't heard from them. Maura goes and takes a closer more detailed look at her guest room. Jane hasn't taken her bag with her. As she looks through Jane's bag she notices the tube of hand cream. She opens and smells it; she thinks it smells quite pleasant. She decides to take the cream back to the office when she goes. She wants to check the level of Ibuprofen in it. On her way back to the station Maura can't contain her fear any longer. She calls Korsack.

"Sergeant, Angela and Jane aren't at home" Maura explains. "I'm very worried about them."

"They've probably just gone to get some lunch Doc," He tries to calm Maura.

"I don't think so; if you'd seen Jane this morning Sergeant there was no way she was going anywhere" Maura explains. Korsack runs through all the options Maura's already considered, when she checks them all off with him, Korsack starts to worry as well.

"I'll brief Cavanaugh Doc; ordinarily it would be too soon to put out an APB but under the circumstances I'm sure he'll approve it" Korsack explains. He adds "I don't care how sick Jane is, if there was danger to her or her mother, she'd have put up a fight." He's trying to reassure himself as much as Maura.

"Korsack I've been to a lot of crime scenes and I'm confident in saying there is no signs of a struggle in my home. If Jane was caught off guard though she might not have had a chance to fight" Maura says; fighting to control her mounting fear.

"I hear ya Doc" Korsack realises Maura's concerns are more than valid.

"I'm about to enter the building Sergeant; I'm just going to drop something into the lab and I'll come straight up" Maura explains. Maura takes Jane's hand cream to Suzie. She asks Suzie to do a substance analysis on the cream. As an afterthought she asks Suzie to check it for the other chemical elements they've been studying in relation to the rape murder cases. Once Suzie is fully briefed, Maura heads upstairs.

"Anything" Maura asks anxiously when she enters the squad room. Korsack is walking back for the Lieutenants office.

"Sean's putting all cruisers on high alert; they're to be on the lookout for Jane" he explains. "Doc who knew Jane was staying at your place and was at home today?"

"Well we all did; then there was only Angela and Jane. Oh wait; Dr. Jackson Hughes. He's Jane's hand doctor I called him this morning and told him about Jane. He was going to call in and see her today, but I've since called him and he said he hadn't had a chance yet."

"How well do you know him" Korsack asks.

"I don't know him that well and I've been meaning to get Jane another doctor. I've been so busy with this case and worried about her, I haven't had the chance. To be honest Sergeant, I don't like him very much. He has a bad reputation as a man; if you know what I mean and not such a great reputation as a doctor either."

Korsack turns to Frost who's concentrating on something on his computer. "Can you run a check on Dr. Jackson Hughes for me Frost?"

"Sorry" Frost looks up; he's clearly been focused on something on his computer.

"What is it Frost" Korsack knows that look on Frosts face.

"You were on the money Doctor Isles. Over the last five years there are three Jane Does and six other identified victims who all match the descriptions of our victims. Two found in Rhode Island, three in Connecticut and the last four were found in Vermont. There has been no cause of death found on these women."

"Can you email me the details Detective Frost, I'll have my team contact the M.E's in those States with our findings and get them to run further analysis" Maura's excited. "If we're lucky he might not have been as careful with other forensic evidence that could lead us to him."

"Good work Frost, once you've done that; can you please run a background check on Doctor Jackson Hughes" Korsack asks.

"Sure, what's this for" Frost asks. He was so engrossed in his computer he hasn't caught on yet that Jane might be missing.

"Frost we can't locate Jane and Angela" Korsack explains. "Hughes is the only person we don't really know that knew Jane was at Maura's place today."

"What!" Frost is immediately worried.

"We're not sure what we're dealing with yet; but Jane matches the description of our victims so I would rather over react and be wrong than not; OK" Korsack outlines.

"Absolutely" Frost jumps straight back on to his computer and starts rapidly punching keys.

Korsack turns to Maura, "all eyes on the streets are looking out for anything. Jane's a highly respected cop Doc, they'll look hard. If he has her… well if he does we have time. We know that. What we have to do is solve this!"

"Of course Sergeant" Maura is feeling sick to the stomach.

"The fact that Angela is missing too gives me hope that they've just gone somewhere and we'll hear from them as soon as they get our messages. Angela does not fit the MO of our perp" Korsack adds.

"I'll go and get those emails out to the ME's in the other States. I'll go back over all the evidence I have. Please call me if you hear anything Korsack" Maura pleads. Korsack squeezes her shoulder as she turns to leave.


When Jane wakes she feels like death. She has a horrendous headache. Her hands are in agonizing pain and she stills has her fever and is nauseous. It dawns on her that her head is resting in some ones lap. As she tries to sit up she becomes aware of an arm resting on her shoulder. It forces pressure to hold her still. It's then she hears her mother, "don't move baby; just lie there please."

Jane looks up to see her mother's tear streaked face above her. "What happened; Ma are you OK" Jane's distressed to see her mother so upset. Jane pushes up from her mother's lap and looks around. They are in a room with padded walls. It's lit by hard lights on the ceiling and in the middle of the roof there appears to be a mirror. Jane recognises it as a one way window. Sitting beside her mother is another woman; she could almost pass as Jane's sister.

Angela speaks "he's going to kill us Jane. He's evil and crazy and he is going to kill us; that's what he told Pauline." Angela's voice is shaking with fear and emotion.

Jane forces her frazzled mind to work. "Whatever you do, do not eat any food he offers. It's poisoned, Maura's sure of it."

A frail voice offers "he gets really angry if you don't eat it." Pauline looks defeated.

At that moment the door opens. "Detective Rizzoli; you are awake. How do you feel, not good I hope." He laughs at her. Jane isn't feeling good at all, a lot worse than she remembers. "You can't fight it Jane, despite your mothers best efforts I've injected you with one of my creations. I enjoy seeing you in pain Jane; I really do!"

Jane looks at her mother and notices bruising around her mouth and chin. Angela is quietly weeping. The anger that boils up in her gives her resolve; she orders her body to fight whatever it is he's injected into her. "What would you like me to call you, you creep. Would you prefer Hughes or Hoyt?" Jane stares at him.

"What do I care, you're not going to be calling me anything for very long." He laughs at her. He watches Jane with delight as he sees her putting together all the pieces. "Yes Jane I have worked on this plan since the day you murdered by brother."

"I get all the sample creams now and I get the pills and the new hand cream; but what about the day we met. How did you manage to get me to drop that six-pack?" Jane is ruing the day she ever crossed paths with Charles Hoyt.

"You are such a creature of habit Jane; you go to the same corner store and buy the same beer every time you go out. Don't you remember I handed you the beer. I had laced the packaging with a very powerful agent; it rendered your hand useless within seconds. The look on your face when you dropped the beer was priceless Jane" he smirks at her.

Jane tries to move towards him but the pain in her hands when she puts weight on them renders her almost useless. "You bastard" Jane offers through clenched teeth.

"It's a delightful bonus to have your dear mummy here. Aren't you a little old to race home to mummy when you're sick, Janey." He reaches out to touch Angela and Jane finds something and springs on Hoyt with all her might. She knocks him off his haunches and uses her elbow to strike a blow at his face. He kicks Jane hard knocking the wind out of her. As Jane falls away he strikes her hard across the face. Angela screams and moves quickly to Jane. He wipes blood from his bleeding nose then laughs "oh yes this is going to be fun." He turns and leaves.


Maura's been dialing Jane's phone every ten minutes. In between she has emailed the chemical elements present in Lilly and Maria's blood plus images of the aneurysms in their Medulla Oblongata to the M.E's in the States Frost identified. She's about to dial Jane again when Frost and Korsack walk in. "Doctor Isles here's what I could find on Hughes. He was born in England in 1976, He emigrated to the States thirteen years ago."

"That's odd," Maura interrupts.

"Really, why" Korsack asks.

"He doesn't have an accent. I mean look at Casey, he was born in England and came here when he was a child. He and Jane went to school together. I still notice his accent, don't you?"

"We've never met Hughes to hear him speak Doc; but yes I do notice Casey's accent" Korsack responds.

Frost chimes back in "he completed his medical training at Oxford in the UK. There was one odd thing I looked into; he has a misdemeanor conviction here in the US. He was caught doing drugs on campus at Harvard. I checked it out and he was doing a unit of his degree here at the time."

"And there's nothing else that stands out to you Frost" Maura asks.

"I'm inclined to agree with your assessment of him Doc; I don't think he's a nice man." Frost responds.

"What do you mean" Maura looks confused.

"He's managed to get out of one sexual harassment case brought on him by a patient. He's was also associated with a Mal-practice suit brought against Mass. General a few years a back. It never went anywhere."

"Huh none of that surprises me Detective Frost; I don't know why Jane would choose him as a Doctor."

"That's all well and good Doc" Korsack suggests, "but none of it ties him to being a kidnapper, rapist or murderer."

"Excuse me Dr. Isles" Suzie has walked into her laboratory.

"Yes Suzie."

Suzie isn't sure whether to speak, "Ah… Dr. Isles you said to keep this information confidential" she hopes Dr. Isles remembers.

"Oh it's OK Suzie." Maura looks at Frost and Korsack. "I did a blood test on Jane the other day; I was worried about her not being able to shake her fever." She takes the report from Suzie. "Oh my God!"

"Dr. Isles the hand cream has the same chemical formula in it." Suzie adds. "I'm just waiting for the other report to print and I'll bring it straight in."

"What's wrong Doctor Isles" Frost asks.

"It's not the same as what killed Maria and Lilly but it's got to be him" Maura says somewhat distracted.

"Sorry Doc" Korsack looks confused.

"Sergeant Detective, I can't yet prove Dr. Jackson Hughes is our rape murderer although I have enough to further investigate a correlation."

"So" Korsack is getting frustrated. "Spit it out Doc."

Maura realises they haven't registered what she's saying. "I can prove that he is the one that's been poisoning Jane."

Korsack and Frost race out, Maura follows closely behind. When they reach the squad room, Frankie and Cooper are there. "What's wrong" Cooper notices the look on their faces.

Korsack doesn't even acknowledge the question. "Frost look up any address, known location; any where he might hide someone" Korsack's exasperated.

"On it" Frost is already clicking away on keys.

"Cooper, you come with me," Korsack looks from Cooper back to Maura. "He was at his office at the hospital when you last spoke to him?"

"That's what he said" Maura sounds frantic. Korsack and Cooper race out.

"What's going on" Frankie looks at Maura. Maura's face is etched with fear; she's fighting the tears that are brimming in her eyes.

"Oh Frankie Jane's been poisoned, that's why she's so sick. We know who poisoned her and we think he could have taken your mother and Jane."

Frankie turns and stares at Frost; Frost looks up at him. "Don't worry man; we'll find her.