Don Cheadle as James "Rhodey" Rhodes / Iron Man: The benefactor of the Avengers, former co-CEO of Stark Industries, and Potts' fiancée who operates the Iron Man armor.

Beth Hoyt as Pepper Potts / Iron Woman: Tony Stark's former assistant, the former co-CEO of Stark Industries, and Rhodes' fiancée who operates the Iron Woman armor.

Chris Hemsworth as Thor: An Avenger and the king of Asgard, based on the Norse mythological deity of the same name.

Mark Ruffalo as Bruce Banner / Hulk: An Avenger and genius scientist who, because of exposure to gamma radiation, typically transforms into a monster when enraged or agitated.

Josh Keaton as Steve Rogers / Captain America: The fugitive leader of the non-regulation faction of Avengers. A World War II veteran, he was enhanced to the peak of human physicality by an experimental serum and frozen in suspended animation before waking up in the modern world.

Lake Bell as Natasha Romanoff / Black Widow: A highly trained spy, member of Rogers' faction of Avengers, and former agent of S.H.I.E.L.D.

Benedict Cumberbatch as Dr. Stephen Strange / Doctor Strange: A former neurosurgeon who, after a car accident that led to a journey of healing, discovered the hidden world of magic and alternate dimensions and became a Master of the Mystic Arts.

Jon Favreau as Happy Hogan / War Machine: An officer in the U.S. Air Force and Avenger who operate the War Machine armor.

Hudson Thames as Peter Parker / Spider-Man: A teenager, Avenger, and Rhodes and Potts' protégé who received spider-like abilities after being bitten by a radioactive spider.

Chadwick Boseman as T'Challa / Black Panther: The king of the African nation of Wakanda who gained his enhanced strength by ingesting the Heart-Shaped Herb.

Paul Bettany as Vision: An android and Avenger created using the artificial intelligence J.A.R.V.I.S., Ultron, and the Mind Stone.

Elizabeth Olsen as Wanda Maximoff: A member of Rogers' faction of Avengers who can harness magic and engage in hypnosis and telekinesis.

Anthony Mackie as Sam Wilson / Falcon: A member of Rogers' faction of Avengers and former pararescueman trained by the military in aerial combat using a specially designed wing pack.

Sebastian Stan as Bucky Barnes / White Wolf: An enhanced soldier and Rogers' ally and best friend who reemerged as a brainwashed assassin after being thought to have been killed in action during World War II. Barnes, formerly known as the Winter Soldier, is given the name White Wolf by the people of Wakanda, who helped remove his Hydra programming.

Tom Hiddleston as Loki: Thor's adopted brother, based on the Norse mythological deity of the same name.

Idris Elba as Heimdall: The all-seeing, all-hearing Asgardian and former sentry of the Bifröst Bridge, based on the Norse mythological deity of the same name.

Peter Dinklage as Eitri: King of the Dwarves of Nidavellir, and weaponsmith, based on the Norse mythological dwarf of the same name. Dinklage reprises his role from Avengers: Infinity War (2018).

Benedict Wong as Wong: A Master of the Mystic Arts, tasked with protecting some of Kamar-Taj's most valuable relics and books. Wong reprises his role from previous MCU media.

Pom Klementieff as Mantis: A member of the Guardians with empathic powers. Klementieff reprises her role from previous MCU media.

Karen Gillan as Nebula: An adopted daughter of Thanos who was raised with Gamora as siblings. Gillan reprises her role from previous MCU media.

Fred Tatascoire as:

Drax: A member of the Guardians and warrior in search of vengeance against Thanos for killing his family.

Corvus Glaive: A member of the Children of Thanos.

Cynthia McWilliams as Gamora: A member of the Guardians who is an orphan from an alien world and was subsequently raised by Thanos, and is seeking redemption for her past crimes. Ariana Greenblatt voices a young Gamora, reprising her role from Avengers: Infinity War (2018).

Vin Diesel as Groot: A member of the Guardians who is a tree-like humanoid.

Bradley Cooper as Rocket: A member of the Guardians who is a genetically-engineered raccoon-based bounty hunter, mercenary, and master of weapons and battle tactics. Cooper reprises his role from previous MCU media.

Benicio del Toro as Taneleer Tivan / The Collector: One of the Elders of the Universe who is an obsessive keeper of the largest collection of interstellar fauna, relics, and species of all manner in the galaxy.

Josh Brolin as Thanos: An intergalactic warlord from Titan who seeks all six Infinity Stones to destroy half of all life for the sake of "re-balancing the universe".

Brian T. Delaney as Peter Quill / Star-Lord: The half-human, half-Celestial leader of the Guardians who was abducted from Earth as a child and raised by a group of alien thieves and smugglers called the Ravagers.

Danai Gurira as Okoye: The head of the Dora Milaje. Gurira reprises her role from previous MCU media.

Okioma Akagha as Shuri: T'Challa's sister who is the inventor of most of Wakanda's vibranium technology.

Mike McGill as Thaddeus Ross: The U.S. Secretary of State, who is hunting Rogers and his faction of Avengers for violating the Sokovia Accords.

Kerry Condon as F.R.I.D.A.Y.: Rhodes and Potts' artificial intelligence, who powers their suits.

Winston Duke as M'Baku: The leader of the Jabari Tribe. Duke reprises his role from previous MCU media.

Florence Kasumba as Ayo: A member of the Dora Milaje.

Jacob Batalon as Ned Leeds: Parker's best friend and guy in the chair.

Isabella Amara as Sally Avril: Parker's classmate.

Tiffany Espensen as Cindy Moon: Parker's classmate.

Ethan Dizon as Tiny McKeever: Parker's classmate.

Samuel L. Jackson as Nick Fury: The former director of S.H.I.E.L.D.

Cobie Smulders as Maria Hill: The former deputy director of S.H.I.E.L.D.

Michael Douglas as Hank Pym: An former entomologist, S.H.I.E.L.D. agent, and physicist who discovered the Pym Particle in the 1960s.

Evangeline Lilly as Hope van Dyne / Wasp: Lang's girlfriend and Pym and Janet's daughter who was passed down the Wasp mantle from her mother.

Michelle Pfieffer as Janet van Dyne: An former S.H.I..EL.D. agent, Hope's mother, and Pym's wife who was stranded in the Quantum Realm for thirty years. Pfieffer reprises her role from previous MCU media.

Alexandra Daniels as Carol Danvers / Captain Marvel: A former U.S. Air Force pilot and Kree/human hybrid who gained superhuman abilities, such as durability, agility, speed, and flight due to absorbing the Tesseract's energy.

Goose: Fury's pet Flerken.

Terry Notary as Cull Obsidian: An member of the Children of Thanos. Notary reprises his role from previous MCU media.

Tom Vaughan-Lawlor as Ebony Maw: An member of the Children of Thanos, with dark magic abilities. Vaughan-Lawlor reprises his role from previous MCU media.

Carrie Coon as Proxima Midnight: The only female member of the Children of Thanos. Coon reprises her role from previous MCU media.

Ross Marquand as Johann Schmidt / Red Skull: The "Stonekeeper" and former Nazi commander of Hydra during World War II. Marquand reprises his role from previous MCU media.

Stan Lee as himself: A school bus driver.

Ross' aide: An aide for Ross.

Kenneth Branagh as Asgardian distress call: The person who records the distress call. Branagh reprises his role from Avengers: Infinity War (2018).