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As the Winchesters search for Pestilence, they are approached byCrowleywho offers to help them find the Horseman through his demon handler Brady; though reluctant to trust the demon, they agree. While Dean is gone, Sam starts considering the idea of allowing Lucifer to possess him in order to force the Devil back into the Cage. Dean and Crowley are able to capture Brady who is supervising testing of the Croatoan virus; Brady is revealed to be possessing a friend of Sam's from Stanford and is the one who murdered his girlfriendJessica MooreonAzazel'sorders in order to force Sam back into hunting. Despite Brady's taunts, Sam is able to restrain himself from taking revenge and when the demon refuses to break, Crowley purposefully reveals their position to demons; following a hellhound attack, held off by Crowley's own hellhound, Brady gives up Pestilence's location. Sam kills Brady and gets his revenge for Jessica's murder while Crowley approaches Bobby Singer with a way to find Death that will require Bobby to sell his soul to the demon and at her place Crowley has his 1st night with charm