In the Solana Galaxy,Chairman Drek and his people, the Blarg, are planning to create a new planet by harvesting parts of other planets in the galaxy. His Machine that creates Sentry-bots malfunctions and accidentally created a small robot. He notice an infobot's prerecorded message. He was caught by the Sentry-bots and fled to the ship.

On the Planet Veldin,A young Lombax mechanic,Ratchet was planning on joining the Galactic Rangers. He notice the Robot has landed here. He hides him from the Sentry-bots,who believe the Bot gets perished. Ratchet named the Bot,Clank.

They found that the Sentry-bots held the rangers engineer,Al captive. Ratchet and Clank saved him. Everyone is impressed of Ratchet and Clank are impressed.

They learned that Captain Qwark went missing. Ratchet and Clank begin their search. They quickly save Skidd McMarks from the Alien Queen. He shows them with infobot,revealing about Drek's Plan: He plan to destroy the planet to create the perfect one. Ratchet reveals to Clank that he never knew his parent since he was found as a baby by the Garage Owner.

They found Qwark at the Planet,Orxon where they were dropped to the lair of the Snagglebeast. Qwark reveals that he was being paid by Drek. They fought against the Beast by sending it to the Lava.

Ratchet and Clank pursues Qwark in his Starfighter. They successfully shot down Qwark's Fighter. They confronts Drek,who confesses that he was responsible for the pollution on Orxon and planning on destroying Veldin.

The two fought with Drek,getting him blasted off to crash land on his new planet. Ratchet and Clank activates the laser to destroy Drek's new planet,killing him.

Ratchet and Clank are hailed as heroes by the People.

Mid-Credits:
Qwark survived the Crash Landing at Florana,although he was unconscious,where he was surrounded by Monkeys.