Tim Roth as Emil Blonsky / Maestro: An Avenger and former Russian-born officer in the United Kingdom's Royal Marines Commandos and U.S. Secretary of State. In the five-year time skip, Blonsky has became another Hulk being who regains his intellect while in Hulk form, calling himself "Maestro", a reference to the Marvel Comics version of the character.

Mark Wingert as Tony Stark / Iron Man: The benefactor of the Avengers who describes himself as a "genius, billionaire, playboy, and philanthropist" with electromechanical suits of armor of his own making.

Josh Keaton as Steve Rogers / Captain America: The leader of the Avengers, World War II veteran and former fugitive, he was enhanced to the peak of human physicality by an experimental serum and frozen in suspended animation before waking up in the modern world.

Mark Ruffalo as Bruce Banner / Hulk: An Avenger and genius scientist who, because of exposure to gamma radiation, typically transforms into a monster when enraged or agitated.

Chris Hemsworth as Thor: An Avenger and the king of Asgard, based on the Norse mythological deity of the same name.

Lake Bell as Natasha Romanoff / Black Widow: An Avenger and a highly trained spy and former agent of S.H.I.E.L.D.

Jeremy Renner as Clint Barton / Hawkeye: A master archer and a former Avenger and agent of S.H.I.E.L.D. who recently served on house arrest.

Don Cheadle as James "Rhodey" Rhodes / War Machine: An officer in the U.S. Air Force and Avenger who operates the War Machine armor.

Paul Rudd as Scott Lang / Ant-Man: A former petty criminal and Avenger who acquired a suit that allows him to shrink or grow in scale while also increasing in strength. As in Avengers: Endgame (2019), Lang was voiced by twins Bazlo and Loen McClair as a baby, by Jackson A. Dunn at age 12, and by Lee Moore at age 93.

Alexandra Daniels as Carol Danvers / Captain Marvel: An ex-U.S. Air Force fighter pilot and Avenger whose DNA was altered during an accident, imbuing her with superhuman strength, energy projection, and flight.

Karen Gillan as Nebula: An adopted daughter of Thanos and Avenger who was raised with Gamora as siblings.

Danai Gurira as Okoye: The general of the Dora Milaje, a group of elite women warriors.

Benedict Wong as Wong: A Master of the Mystic Arts and a companion of Stephen Strange / Doctor Strange.

Jon Favreau as Happy Hogan: The former head of security at Stark Industries and Stark's friend and former chauffeur.

Bradley Cooper as Rocket: A member of the Guardians and Avenger who is a genetically engineered raccoon-based bounty hunter, mercenary, and master of weapons and battle tactics.

Beth Hoyt as Pepper Potts / Rescue: Stark's wife, Morgan's mother, and the CEO of Stark Industries. Potts wears a weaponized powered exosuit of armor made for her by Stark.

Josh Brolin as Thanos: An intergalactic warlord from Titan who acquired all six Infinity Stones and triggered the Snap, killing half of all life in the universe.

Benedict Cumberbatch as Dr. Stephen Strange / Doctor Strange: A former neurosurgeon who, after a car accident that led to a journey of healing, discovered the hidden world of magic and alternate dimensions and became a Master of the Mystic Arts.

Chadwick Boseman as T'Challa / Black Panther: The king of the African nation of Wakanda who gained his enhanced strength by ingesting the Heart-Shaped Herb.

Hudson Thames as Peter Parker / Spider-Man: A teenager, Avenger and Stark's protégé who received spider-like abilities after being bitten by a radioactive spider.

Cynthia McWilliams as Gamora: A member of the Guardians who is an orphan from an alien world and was subsequently raised by Thanos, and is seeking redemption for her past crimes. This version is an alternate time-traveling version from 2014.

Elizabeth Olsen as Wanda Maximoff: A member of Rogers' faction of Avengers who can harness magic and engage in hypnosis and telekinesis.

Anthony Mackie as Sam Wilson / Falcon: A member of Rogers' faction of Avengers and former pararescueman trained by the military in aerial combat using a specially designed wing pack.

Sebastian Stan as Bucky Barnes / White Wolf: An enhanced soldier and Rogers' ally and best friend who reemerged as a brainwashed assassin after being thought to have been killed in action during World War II.

Tom Hiddleston as Loki: Thor's adopted brother, based on the Norse mythological deity of the same name. This version is the villainous version of the character from the aftermath of the Battle of New York in 2014, who has not undergone the original Loki's events, such as imprisonment on Asgard and fighting the Dark Elves in Thor: The Dark World (2013) and helping Thor stop Hela on Asgard in Thor: Ragnarok (2017).

Pom Klementieff as Mantis: A member of the Guardians with empathic powers.

Fred Tatascoire as:

Drax the Destroyer: A member of the Guardians and warrior in search of vengeance against Thanos for killing his family.

Corvus Glaive: A member of the Children of Thanos, who wields a glaive.

Okioma Akagha as Shuri: T'Challa's teenage sister, who is in charge of developing Wakanda's technology powered by vibranium.

Maria Hill: The former deputy director of S.H.I.E.L.D.

M'Baku: The leader of Wakanda's mountain tribe, the Jabari.

Tom Vaughan-Lawlor as Ebony Maw: A member of the Children of Thanos, who uses dark magic.

Ned Leeds: Parker's best friend and classmate.

Vin Diesel as Groot: A member of the Guardians who is a tree-like humanoid.

Brian T. Delaney as Peter Quill / Star-Lord: The half-human, half-Celestial leader of the Guardians who was abducted from Earth as a child and raised by a group of alien thieves and smugglers called the Ravagers.

Samuel L. Jackson as Nick Fury: The director of S.H.I.E.L.D. and Danvers' friend and ally.

Ross Marquand as Johann Schmidt / Red Skull / Stonekeeper: A Nazi general and lieutenant during World War II and the former leader of Hydra, who is in charge of protecting and guarding the Soul Stone on Vormir.

Terry Notary as Cull Obsidian: A member of the Children of Thanos, who wields a war hammer.

Kerry Condon as F.R.I.D.A.Y.: Stark's artificial intelligence (AI) system.

Carrie Coon as Proxima Midnight: A member of the Children of Thanos, who wields an electric staff.

Evangeline Lilly as Hope van Dyne / Wasp: The daughter of Hank Pym and Janet van Dyne who is handed down the Wasp suit and mantle from her mother.

Tessa Thompson as Valkyrie: The de facto ruler of New Asgard and a member of the Valkyrie, Asgard's all females task force and security force.

Rene Russo as Frigga: The wife of Odin, queen of Asgard, mother of Thor, and adoptive mother of Loki, based on the mythological deity of the same name.

John Slattery as Howard Stark: Stark's father and the founder of Stark Industries, who worked on Project Rebirth and the Manhattan Project during World War II (WWII).

Tilda Swinton as The Ancient One: The previous Sorcerer Supreme and Strange's mentor.

Hayley Atwell as Peggy Carter: Rogers' World War II (WWII girlfriend and a former director of S.H.I.E.L.D.

Marisa Tomei as May Parker: Parker's aunt.

Taika Waititi as Korg: A Kronan and ally of Thor.

Angela Bassett as Ramonda: The queen mother of Wakanda and T'Challa and Shuri's mother.

Michael Douglas as Hank Pym: An entomologist, physicist, and former S.H.I.E.L.D. agent, who became the original Ant-Man after discovering the subatomic particles that make the transformation possible.

Michelle Pfeiffer as Janet van Dyne: Pym's wife, Hope's mother, and the original Wasp, who was trapped for 30 years in the Quantum Realm.

Linda Cardellini as Laura Barton: Barton's wife, Cooper, Lila, and Nathaniel's mother, and a former agent of S.H.I.E.L.D.

Maximiliano Hernández as Jasper Sitwell: An agent of S.H.I.E.L.D. and Hydra sleeper agent.

Frank Grillo as Brock Rumlow: An agent of S.H.I.E.L.D. and S.T.R.I.K.E. and Hydra sleeper agent.

Robert Redford as Alexander Pierce: The secretary of the World Security Council, Fury's superior and liaison between S.H.I.E.L.D. and the World Security Council, and the secret director of Hydra.

Jack Rollins: An agent of S.H.I.E.L.D. and S.T.R.I.K.E., and Hydra sleeper agent.

Harley Keener: A teenager from Rose Hill, Tennessee, who worked with Stark during the Mandarin incident to stop A.I.M.

Kraglin: A member of the Ravagers, who uses a electrokinetic arrow and control fin.

Natalie Portman as Jane Foster: An astrophysicist and Thor's ex-girlfriend who they extract the Reality Stone from.

James D'Arcy as Edwin Jarvis: The butler for the Stark family, who is modeled after Stark's original artificial intelligence, J.A.R.V.I.S.

Hiroyuki Sanada as Akihiko: A Yakuza boss operating in Tokyo who opposes Barton.

Lexi Rabe as Morgan Stark: Stark and Potts' 5-year intelligent daughter.

Emma Fuhrmann as Cassie Lang: Lang's 16-year-old daughter.

Stan Lee as himself: A driver from the 1970s, who says "Make love, not war" to a passing Stark and Rogers.

Ken Jeong as a security guard: A security guard at the storage facility.

Yvette Nicole Brown as S.H.I.E.L.D. agent: An agent of S.H.I.E.L.D. from 1970 New Jersey.

Joe Russo as grieving gay man: A grieving gay member of Rogers' group therapy session.

Ava Russo as Lila Barton: Barton and Laura's daughter.

Lia Barton as Hulk and Maestro fan: A fan of the Hulk and Maestro.

Jim Starlin as himself: A grieving man and member of Rogers' group therapy session.

Howard the Duck: An anthropomorphic duck-like creature and member of the Ravagers.

MJ: Parker's classmate and girlfriend.

Jake Gyllenhaal as Quentin Beck / Mysterio: A former Stark Industries employee and holographic-illusions specialist who masqueraded as a superhero from Earth-833 in the multiverse. Gyllenhaal reprises his role from previous MCU media.

J.K. Simmons as J. Jonah Jameson: The host of The Daily Bugle. Simmons reprises his role from previous MCU media.

Ben Mendelsohn as Talos: A Skrull and ally of Fury and Danvers, who impersonated the former. Mendelsohn reprises his from previous MCU media.

Sharon Blynn as Soren: A Skrull, Talos' wife, and ally of Fury and Danvers, who impersonated Maria Hill. Blynn reprises his role from previous MCU media.

Teyonah Parris as Monica Rambeau: A Captain for S.W.O.R.D. and the daughter of Maria Rambeau, Danvers' best friend. Parris reprises her role from previous MCU media.

Evan Peters as Ralph Bohner: A Westview resident under Agatha Harkness' control, who posed as Wanda's deceased twin brother Pietro. Evans reprises his role from the Disney series WandaVision (2021).

Josh Stamberg as Tyler Hayward: The acting director of S.H.I.E.L.D. investigating the Westview situation. Stamberg reprises his role from the Disney series WandaVision (2021).

Randall Park as Jimmy Woo: An FBI agent working with S.W.O.R.D. who previously was Lang's parole officer. Park reprises his role from previous MCU media.

John Walker / U.S. Agent: A decorated Captain of the U.S. Army Rangers who was chosen by the U.S. government to be Captain America until being stripped of the title.

Emily VanCamp as Sharon Carter / Power Broker: A former agent of S.H.I.E.L.D. and the CIA, and Peggy Carter's niece, who has become the criminal leader of Madripoor known as the Power Broker.

Richard E. Grant as Classic Loki: An old Loki variant who faked his death to escape being killed by Thanos and decided to live his life in seclusion until he became lonely. Grant reprises his role from the Disney series Loki (2021–23).

Boastful Loki: A Loki variant who makes wild exaggerations about his accomplishments.

Kid Loki: A young variant of Loki who created a Nexus event by killing Thor and considers himself the king of the Void.