Though Lucifer and Chuck are reluctant to work together, Chuck eventually admits Lucifer was his favorite who he thought would be strong enough to bear the Mark of Cain. When that was proven wrong, Chuck was angry at himself, confessing that was part of the reason he banished Lucifer along with protecting humanity. With Michael in no condition to fight and not enough time to revive Raphael and Gabriel, Lucifer/Castiel and the Winchesters recruit the angels in Heaven, Crowley's forces, and Rowena and a few witches. Despite their bickering they all agree to weaken Amara and allow Chuck to trap her in the Mark. Since both Chuck and Amara are essential to reality, Chuck won't kill her and wants to seal her within the Mark to be carried by Sam this time. Though Dean protests, he eventually agrees. Amara eats Donatello's soul and breaks into the bunker but willingly follows Rowena's trap to find her brother. Amara kills the other witches and walks away from both the angels' combined smite and an assault from Crowley and his demons. However, the combined attacks of everyone weaken her enough that she is prepared to be banished by Chuck. She laments how she did love her brother and gets him to admit that part of the reason he created things was to rule over them, and that he hated how they were equals. She resists when Chuck tries to seal her into Sam, stopping the Winchesters, apparently killing Lucifer and gravely wounding Chuck. Amara warns Chuck is not dead yet because he is going to watch her destroy everything ever created.