Unlike Blissey, who are seen as a natural pokemon center and therefore beloved by all living things, Togetic are not associated by most Pokemon with happiness. For ancient pokemon like Kabuto and Omanyte, they were a source of fear, a predator who could command plant life and slice through their shells from afar with leaves, then feast on the remains. Most modern pokemon regard Togetic with mild indifference, finding them far too rare to be a source of any emotion save for curiosity. And then there is Man, who considers them a good luck charm across all cultures and has dubbed them the "Happiness Pokemon".

It is mysterious that humans would think so highly of Togetic. Unlike many other beloved pokemon such as Growlithe and Pikachu, this appeal to humans did not develop as a result of their domestication; indeed, most pet Togetic predate their owners by millions of years! The effect of Togetic can not be reproduced even in other humanoid pokemon such as Jynx or Mankey, yet it is undeniably real: clinical trials have shown that the presence of a Togetic actually outperforms most antidepressants in humans.

Although there is not yet consensus on the matter, an increasing body of evidence has begun to suggest that domestication is the source of this strange phenomenon; it is simply that Togetic were not the ones domesticated. This theory has been pilloried for its troubling implications, but even those who deny it accept some kind of symbiosis between Togetic and early man. The paucity of shiny stones in this era led to a lack of Togekiss mothers, so before we invented weapons and pokeballs, we cared for Togepi, and were rewarded with happiness when they evolved.