In the early days of Pokemon contests, before there were Poffins and Pokeblocks, berries were turned into appeal-enhancing items through the use of live Shuckle. Shuckle are a pokemon which naturally cause berries to turn into a juice which has its own beneficial effects when prepared properly. In pokemon and humans alike, it restores health and cures illness, and further fermentation allows it to be turned into a hard cider which has replaced beer and wine on Cinnabar Island.
This process took far too long for most coordinators, who instead used the hole on a Shuckle's back to stir a mix of berries with a stylus while swinging the pokemon around until it became dizzy; dizziness signified that the Shuckleberry was completed. Although Shuckle are more than sturdy enough not to be harmed by this technique, many find it so annoying that they hide under rocks whenever a coordinator, or indeed a trainer (for they can not tell them apart) passes by.
Competition between cider brewers and coordinators combined to virtually wipe out the wild population of Shuckle, a problem compounded as increasing shortages changed the process from one of using wild Shuckle to one of capture to secure one for future usage. In time, the brewers won out, and other methods were developed to allow contest pokemon to make use of berries. But among a select few coordinators on Cinnabar, the ancient art of Shuckleberries continues, using Shuckle passed down as heirlooms for generations.