Mike West as Fox McCloud, James McCloud, ROB64
Alesia Glidewell as Krystal, Kursed, Aparoid Queen
Mark Lund as Falco Lombardi
Lyssa Browne as Slippy Toad, Katt Monroe
Katy Mixon as Amanda Toad
Jaz Adams as Peppy Hare, Bill Grey
Keith Szarabajka as Kronos Kudrov, Morane
David Sobolov as Radoven Neigora
Jay Ward as Wolf O'Donnell
Ja Green as Leon Powalski
Kavus Torabi as Panther Caroso
Gwendoline Yeo as Miyu Lynx
Katie Griffin as Fay Grissom
Mark Hamill as Kaden, Chermaya, Baphomet
Gary Chalke as Ryan Lynx
Ming Na-Wen as Khatru "Kathy" Lynx
Kath Soucie as Fara Phoenix
Timothy Olyphant as Adrian Essex
Kari Wahlgren as Connie Alvarez
Gary Anthony Williams as Ron Hayward, additional voices
Jim Cummings as Richard Varner
David Morse as Garth Woods
Dee Bradley Baker as Charles Warren, Zkauba
John DiMaggio as Roy Watkins
Dorian Harewood as Jerome Jones
Grant Albrecht as Phantom/Dascal Zunda, additional voices
David Frederick White as Andross
Dave Fennoy as Maizner Synn
Stephen Stanton as Zarran Synn, Hyen Zunda, Randolph Carter
Mads Mikkelsen as Director Haydar Kazan
David Scully as Tolan, additional voices
John Silke as General Scales
Eamon Hunt as General Reza Cordelia
Michael Ironside as Krav Bishkesk
Kevin Michael Richardson as Voldrak, Krahl
Lars Mikkelsen as Lord Madras Synn
Michael Bell as General Shade Turant/Feldon Drexler, President Thompson
Clancy Brown as Eugene Clegg
Debi Mae West as Vixy McCloud
Adam Baldwin as Doug Grissom
Robin Atkin Downes as The Colour Out of Space
Andy Serkis as Cthulhu
David Zayas as Hugo Zayas
Mary Elizabeth McGlynn as Rena Mouradian
Vanessa Marshall as Carmen Sanders
Thomas F. Wilson as Algy Hoffman
Jeff Bennet as Zeke Cairns
Ted Levine as Heinrich Zoll
Jaime King as Aurra Sing
Jonathan Banks as Volg Kozan
Ron Perlman as Ozric Maynard
Lex Lang as Vark