Assassin's Creed: Rebirth
Akatsuki vs. the Brotherhood
Madara/Obito vs. Sasuke and/orNaruto
When Desmond Miles activated the Temple to protect the Earth from the sun's wrath, he unknowingly initiated the creation of a monster of unfathomable power. It was a creature that was fueled by the sheer power of the sun, the Juubi. For almost five years, the Juubi rampaged upon the Earth (destroying and altering the planet's appearance and landmasses) until finally Desmond found a way of subduing it by using one of the First Civilization's 'failed' processes. He was able to seal the Juubi's power within himself, making him the first Jinchuuriki ever, and entrapping the Juubi's body within the moon itself.
He would spend the rest of his life journeying across the world, helping people rebuild. Using a Piece of Eden, he began bestowing special powers and abilities upon them to help them build and help them to learn how to use these powers. Over the years, the people began to revere him as a god. Shortly before his inevitable death, he divided the Juubi's power into nine smaller portions and gave life to them. On his death bed, Desmond named his younger son his heir, believing that peace and love was the surest way to return the world back to its former state. Unknown to Desmond though, his son was a traitor, a Templar searching for the Pieces of Eden.
Over the following millennia, the Assassins and Templars would continue their endless battles, in one form or another. Eventually, the two forces would finally tire of their endless war and try to create peace. With the alliance of the Senju, modern counterparts of the Templars, and the Uchiha, descendants of the Assassins, Konoha was formed. But, plots and treachery within the Senju (Root, the true Templar Order) eventually led to the near-extinction of the Uchiha.
On the night of the Uchiha Massacre, Itachi, fearing for his brother's life, made the leader of the secret Templar Order (Shimura Danzo) swear to never harm his brother. Believing that he had the upper hand and could sway Sasuke into his organization, Danzo agreed. What he didn't anticipate was Itachi kidnapping Sasuke and bringing him to one of the few remaining non-Uchiha Assassins to have Sasuke trained.
During his explorations, Itachi made a terrifying discovery. Uchiha Madara, alive, leading a secret organization that was heavily modeled after the original Templar Order, also seeking to control the world in some obscure way.