Appearances
Featured characters:
Spider-Man (Peter Parker) (First and only known appearance)
Supporting characters:
Harry Osborn (First and only known appearance)
Gwen Stacy (First and only known appearance) (Voice only)
Antagonists:
Sinister Five (First and only known appearance)
Sandman (Flint Marko) (First and only known appearance)
Vulture (Adrian Toomes) (First and only known appearance)
Doctor Octopus (Dr. Otto Octavius) (First and only known appearance)
Electro (Max Dillon) (First and only known appearance)
Mysterio (Quentin Beck) (First and only known appearance)
Oscorp (First and only known appearance)
Gentleman (Gustav Fiers) (Behind the scenes)
Other characters:
Aunt May Parker (Cameo) (Only in flashback)
Uncle Ben Parker (Cameo) (Only in flashback)
Richard Parker (Mentioned) (Only in main story and flashback)
Mary Parker (Mentioned) (Only in main story)
Captain George Stacy (Mentioned) (Deceased in main story)
Lizard (Dr. Curt Connors) (Mentioned)
Norman Osborn (Mentioned) (Deceased in main story)
Races and Species:
Humans (homo sapiens) (First and only known appearance)
Humans/spider hybrids (First and only known appearance)
Locations:
Earth (First and only known appearance)
North America (First and only known appearance)
United States of America (First and only known appearance)
New York (First and only known appearance)
New York City (First and only known appearance)
Midtown (First and only known appearance)
Harry Osborn's Apartment (First and only known appearance)
Bank (First and only known appearance)
United Kingdom (First and only known appearance)
England (First and only known appearance)
London (First and only known appearance)
Peter Parker and Gwen Stacy's Apartment (First and only known appearance)
Items:
Spider-Man's Suit (The Amazing Spider-Man 2) (First and only known appearance)
Spider-Man's Web-Shooters (The Amazing Spider-Man film series) (First and only known appearance)
Syringe (First and only known appearance)
Electro's Suit (First and only known appearance)
Vulture's Suit (First and only known appearance)
Vulture's Flight Harness (First and only known appearance)
Doctor Octopus' Mechanical Arms (First and only known appearance)
Mysterio's Suit (First and only known appearance)
Vehicles:
N/A
Organizations:
Sinister Five (First and only known appearance)
Daily Bugle (First and only known appearance)
Oscorp (First and only known appearance)
Events:
Murder of Ben Parker (Mentioned)
Assassination of Richard and Mary Parker (Referenced)
Lizard's Cross-Species Agenda (Mentioned)
Confrontation at Oscorp Tower (Referenced)
Sacrifice of George Stacy (Referenced)
Bank Robbery in Midtown (First and only known appearance)
Plot
At Harry Osborn's apartment, Peter Parker / Spider-Man reveals his secret identity to Harry and gives him his blood to keep him alive at the risk of Harry dying.[a] After initially refusing, Harry's lecture about hope and heroism reminds him of a conversation that Ben had before he died.[b] He offers it on the condition that Harry will not replicate his blood, which he agrees to. Harry offers him money so he can go with Gwen Stacy to Cambridge University, which he reluctantly accepts. In London, Peter sees on the news that the Sinister Five — Flint Marko / Sandman, Adrian Toomes / Vulture, Dr. Otto Octavius / Doctor Octopus, Max Dillon / Electro, and Quentin Beck / Mysterio, have stolen technology from Oscorp and are using it to commit crimes. Peter believes that Harry is behind it and he faces off against them.
Cast
Andrew Garfield as Peter Parker / Spider-Man: An orphaned teenage boy who received spider-powers after being bitten by a genetically altered spider. Peter first uses his powers to try to hunt down the killer of his uncle in The Amazing Spider-Man but soon decides to use his powers to fight crime as the vigilante known as Spider-Man.
Dane DeHaan as Harry Osborn: Peter's best friend for 10 years and son of Norman Osborn. He was sent away to boarding school around the same time Peter's parents disappeared and met him for the first time there.
Emma Stone as Gwen Stacy: Peter's girlfriend, who is attending Oxford University in London.
John Cena as Flint Marko / Sandman: A small-time crook, who after an accident with a super collider, gained the ability to control and manipulate sand.
Ben Kingsley as Adrian Toomes / Vulture: A jewel thief and member of the Sinister Five, who steals a flight harness from Oscorp.
Javier Bardem as Dr. Otto Octavius / Doctor Octopus: An Oscorp scientist, physicist, and atomic scientist who after an accident, was fused to four mechanical arms.
Jamie Foxx as Max Dillon / Electro: A former electrical engineer who worked for Oscorp Industries and later transformed into a powerful, electrical creature following an accident, then taking the alias of "Electro".
Zachary Quinto as Quentin Beck / Mysterio: An actor and former special effects artist who uses a suit to commit crimes and a member of the Sinister Five.
Sally Field as Aunt May Parker: Parker's aunt and Ben's wife. She appears through archival footage from The Amazing Spider-Man (2012).
Martin Sheen as Uncle Ben Parker: Parker's uncle and May's husband, who was killed by a crook Peter accidentally let rob a deli. He appears through archival footage from The Amazing Spider-Man (2012).
Notes
a. This choice is when the events diverge from the film The Amazing Spider-Man 2 (2014).
b. As depicted in The Amazing Spider-Man (2012).