Just got the idea for a Highlander/Prototype Crossover. Not sure what character to use for it, Alex, an SI, or an OC.
The premise is that when Alex throws down the Blacklight virus at Penn Station, it spreads far faster than anyone could have anticipated. A whole lot of people died, and a whole lot of people got turned into runners just like Alex did. Runners can sense each other kind of like Highlander using the Hunter Pulse. The instinct to survive is strong, and all the runners quickly discover that absorbing another runner gives them new powers and abilities, while absorbing normal humans and the Red Light infected have a very low chance of giving abilities and simply give more mass and make you slightly stronger.
On top of all this, the runners have to deal with a competent and very dangerous Blackwatch, and as the human population decreases more and more thanks to the spread of the Redlight virus, nuclear intervention is a very real possibility thanks to Blackwatch's sole orbital nuclear missile platform, though as Blackwatch moves more and more resources to space, including a mining operation in the asteroid belt, the possibility of multiple orbital platforms is a very real possibility in the future.
From the perspective of Alex, I suppose I'd write him trying to destroy all the other runners so that he's the only one left in order to fix his mistake.
From the perspective of an SI/OC, I suppose I'd write them as being hit by the initial spread of the blacklight virus, and them trying to figure out what's going on and survive the situation they've been thrust into. Whether they'll survive to become the last Runner remains to be seen.