A Photojournalist,Frank West was in the helicopter with a pilot,Ed DeLuca,& learned that the town is quarantined due to a Zombie Outbreak. He was later dropped at the mall where he meets a researcher,Doctor Russell Barnaby,a Janitor,Otis Washington,a DHS Agent,Brad Garrison,& his partner,Jessica McCarney. Frank begun searching for more survivors as the Zombies breached in. Brad warns him about the Zombies aren't the only ones,but psychotic survivors as well.

Frank sees a woman being held captive by a mad manager,Steve. After Frank kills him,the woman introduced herself as Isabela Keyes,sister of the unknown assailant,Carlito,& promise to set up an interview between the two. They are both ambushed by Psychos,but manage to escape when the Zombies attacks them. Isabela reveals that Santa Cabeza was home to an American researcher facility experimenting on cattle & that Barnaby was its head. She used to be a research assistant & the fact that a species of native wasp was used in an attempt to boost the zombifying effect,but they escaped & infected humans,forcing a U.S. Military cleanup of all life in town,with few escapees.

Barnaby begins to zombify before Brad was forced to kill him. While avoiding the zombies,Jessie was killed by Carlito,who reveals that he'll be using bombs to destroy this place & has the psychos in hoping to kill Isabela. Frank & Carlito engaged in a shootout while Brad & Isabela disable the bombs. After Carlito is wounded,A Psycho Butcher,Larry kills him. Frank manage to kill him as Isabela shuts down the jammer. However,U.S. Special Forces arrive in the mall regardless & have cleanup orders. Otis,Brad,Frank,Isabela,& other survivors escapes in the helicopter.

Later at the Military base,Frank was informed by DeLuca about a strange incident going on at the city caused by an unidentified corporation.