OK addressing some of the question in the reviews Humanimals are the uplifted anthro animal race of the dimension of First Earth as opposed to Third Earth where the Turtles live Humanimals are made a very specific way as opposed to Mutant Animals who are more hodgepodge and mutated a variety of different ways...One way to think of it is the different between a named brand like say a Gucci dress and the sweater your grandma knitted for you, Mizzer Humanimals are specifically Humanimals from the Planet Mizzer AKA my 90s Nostalgia Planet where the Humanimals have a very unique culture not only because they had been living like it was the 1990s for five thousand years but because the Neo-Hippy Humans took those first animals freshly transformed from ordinary animals away from Earth when Earth first declared Humanimals to be slaves of humans so being raised in isolation from the rest of the 'Empire of Humanity' for the longest time not knowing anything about Humanimals being slaves everywhere else in human-colonized space meant the Mizzer Humanimals have five thousand year to able to practice living like normal humans working normal jobs and being paid a salary and living in nuclear families a lot of this is fleshed out a lot more in my original stories on Fictionpress, does this explanation make sense?

Rover then said "I'm sure Little Mac will accept you for who you are...I mean obviously he was a little shocked to realize you were actually a Mutant but I know Little Mac and he's totally cool with us!"
Bimbette sighed but smiled at Rover's assurances.

"Anyway…" The Mutant Wolf said as he stood up "...I'm going to leave before Mac gets here...Just wanted to make sure you were ready before he arrived."
"Au revoir…" Bimbette said quietly as Rover left indulging in a little French after so many years of speaking English while living among American Mutants...She quickly checked herself in the mirror to make sure she was ready, making sure her head-fur looked neat and smoothing her Aqua colored tank top.

When Little Mac finally arrived Bimbette practically leapt to the door to answer it.

"Hi Little Mac…" Bimbette said quietly

"Hi." Little Mac said as he was taken a bit aback by how her voice sounded now "Your...Accent seems to have changed."
"Yeah." Bimbette sighed as she let Little Mac into her tree apartment "Living among American Mutants for years will do that to you…"
And that was when Little Mac realized, that for most of his International Fellow Boxers it was probably an actual effort to keep their accents as it was part of their personas at the WVBA...And they probably made sure to visit their home countries as a way to renew their accents like drawing water from the ancestral well…

"Um…" Little Mac rubbed his arm "So...How you been?"
"Wandering the wilderness, sometimes with fellow Mutants, sometimes alone but the migrating all over the North American continent was a strategy to keep one step ahead of those like Feral and Bishop." Bimbette said "How have you been?"
"Well…" Little Mac said "...Things have been kind of dull since I stepped down from being the WVBA Champion…"
"WHAT?!" Bimbette's white tail went up and all floofed "You actually did it?!"
"You didn't know?" Little Mac asked

"No!" Bimbette said "I was frequently deep in the wilderness! I had no way to watch TV or even find a newspaper!"
And Little Mac felt a bit ashamed not taking that into account "So...I rose through the ranks and became the youngest champion in 2005…" He sighed "...But I eventually quit when I lost three times defending my title, first to Don Flamenco, then to Super Macho Man and finally to Disco Kid which was the final straw it was getting to be too much stress...But now...I just kind of...I don't know what to do with myself now...I fulfilled my lifelong dream...But now what do I do with the rest of my life?"

So there is my interpretation of who Mac would most likely canonically lose to in Mac's Last Stand Don Flamenco and Super Macho Man both had the biggest vendettas against Mac...While losing to Glass Joe would be hilarious I thought it would be still to unlikely and it is kind of poetic/fitting as Disco Kid is the other Boer from NYC so there might be a sense that Mac let himself lose to Disco Kid as they were both New Yorkers