In one timeline, the only thing the world would know of Ashley Graham was her harrowing ordeal at the hands of Los Illuminados. In another, her destiny is changed by a meeting with an alien stranger. With a new friend, college courses to manage, and secret service to dodge, Ashley finds herself escaping her quiet life shadowed by politics, and taking the trip of a lifetime.

The TARDIS takes the Doctor to the derelict, luxury cruise liner the Cairo at the same time as Leon Kennedy arrives on the same ship to investigate why all contact was recently lost with this luxury cruise liner turned Umbrella mobile research facility.

A wrong turn from the TARDIS lands the Doctor right into the one place that humanity should never have created...and is the one place that everyone wants to have in their possession.