The Calamity Trio and Arthurian Brothers
Anne Boonchuy-Brenda Song
Marcy Wu-Haley Tju
Sasha Waybright-Anna Anakana
Danny-Greg Cipes
Tony- Brad Swaile
Lucas-Jace Norman
Wartwood
Sprig-Justin Felbringer
Hop-Pop-Bill Farmer
Polly-Amanda Leighton
Wally-James Patrick Stuart
Toadstool-Stephen Root
Toadie-Jack MrBrayer
Toad Tower(s)
Grime-Troy Barker
Percy-Matt Jones
Braddock- Kristen Johnson
Bog-Darn De Paul
Fens-April Winchell
Beatrix-Aisling Bea
Bufo-Daisuke Tsuji
Aldo-Ron Cephas Jones
Newtopia
Andrias- Keith David
Lady Olivia-Michelle Dockery
General Yunan-Zehra Fazal
Javi-Jack De Sena
Kettle- Jennie Kwan
Albert- Sab Shinomo
Earth-Civilians
Oum Boonchuy- On Braly
Bee Boonchuy-Brian Sounalath
Mrs. Waybright-Deedee Magno
Mollie Joe Waybright- Cassie Glow
Robert Otto-Brad Garret
Mr. Wu- Eric Bauza
Mrs. Wu-Sumalee Montano
May Parker-Marisa Tomei
X-Men
Professor X-Patrick Stewart
Scott Summers/Cyclops-Tim Pocock
James "Logan" Howlett/Wolverine- Hugh Jackman
Kurt Wagner/Nightcrawler-Alan Cumming
Hank McCoy/ Beast-George Buza
Jean Grey-Sophie Turner
Ororo Monore/Storm- Halley Barry
Rouge-Ana Paquin
Peter Rasputin/ Colossus-Stefan Kapičić
Magento-Ian Macallan
Nega-Sonic Teenage Warhead-Brianna Hildebrand
Yukio-Shiori Kutsuna
X-Factor/New Mutants
Emma Frost-Kari Walhgren
Sean Cassidy/Banshee-Caleb Landry Jones
Danielle Moonstar/Mirage- Blu Hunt
Rahne Sinclaire/Wolfsbane-Maise Williams
Illyana Rasputin/Magik- Anya Taylor Joy
Sam Guthrie / Cannonball- Charlie Heaton
Roberto da Costa / Sunspot-Henry Zagha
Alex Summers/ Havok-Lukas Till
Forge-Gil Birmingham
Jubilee-Lana Kondor
Other Heroes
Spider-Man-Tom Holland
Trini Kwan-Becky Gomez
Jason Scott-Darce Montgomery
Kimberly Heart-Naomi Scott
Zack Taylor-Ludi Lin
Billy Cranston-RJ Cyler
Tommy Olivier-Khadijha Red Thunder
Mr. X-RuPaul
Deadpool-Ryan Renolds
Sam Wilson/Captain America- Anthony Mackie
Dr. Strange-Benedict Cumberbatch
Wong-Benedict Wong
Major Villains
Mr. Sinister-Chris Britton
Apocalypse-David Kaye
Ramrod-Matthew David Rudd
Ruckus-Dan Hennasey
Hairbag-John Blackwood
Slab-Phil Parsons
Gorgeous George- Rod Wilson
Vertigo-Megan Smith
Golden Mask-Jim Cummings
Larry Trask- Xander Mobus
Benedict Waybright-Alan Cumming
Dr. Frakes- Cree Summer
Subject to change/expansion, more on the way!
If you don't see a voiced character here, assume they're the same as usual. All the characters listed here are major players, with at least one storyline involving them.
While mostly sticking to the MCU/Fox movies, a few characters' actors were taken from animated series due to being more in line with what we have in mind.
Also, yes, there is a reason Nightcrawler and Benedict share the same actor; they will be foils to each other.
See you next time!