The Madness of Karamazov
If there is anything that may even remotely be considered a gene-curse of sorts, it is the cursed Madness of Karamazov that has consumed Inquisitor after Inquisitor. It is unknown if it is only an affliction that occurs amongst the followers that we have yet to purge, or if it is an affliction that touches the most fanatical amongst the Ordos, or something else entirely... in any case, it has swiftly become the bane of the Ordos.
It usually begins with an increasing interest in combating heresy. An innocent enough symptom that grows into something horrific. Usually this stage is not noticed by other colleagues, but as this is the stage where the madness is most treatable, we have started to regularly use Panacea and psykers to try to detect this Madness and stop it here.
The second stage is the egomania. The Inquisitor starts becoming proud and haphazard, executing suspected heretics at first sight. This is when they start constructing their solid gold statue of Karamazov and mobile "throne".
The third stage is when the embezzling begins to occur. The afflicted Inquisitor starts building a fleet in order to travel to the heretical systems of the Cainite Protectorate in order to purge it, no matter the cost. This is where most of the embezzled money goes to, though a small portion ends up completing the statue and throne.
The fourth stage is when they start obsessing over Lady Inquisitor Amberley Vail, and how to best execute her and her colleagues and underlings. The Inquisitor is fully afflicted now, and anything that has interacted with Cain is now heretical in their eyes, and that would include Lady Vail.
Additional section written by Inquisitor Bessek
One key difficulty with Inquisitors who reach the later stages is that they cannot be trusted to hold to regular Panacea treatments, and from the third stage on refuse to tolerate its usage in their presence at all, because the Panacea STC template was seized from a Cainite facility by Inquisitor Vail (something that causes fourth stage sufferers to seek to purge the Panacea from Imperial worlds). As a result, unwillingness to use and/or take the Panacea is often an early indicator of this condition...