The Cooper Gang broke into the Cairo Museum of Natural History in order to steal the Clockwerk Parts. They are caught by Inspector Carmelita Fox & Constable Neyla,who mentioned that the parts have already been stolen by the Klaww Gang. The Cooper Gang escape & track down one of the Klaww Gang members,Dimitri Lousteau in Paris. Sly was confronted by Neyla,who claimed that she wanted to help them collect the parts. After Sly defeats Dimitri,He collected the Clockwerk tail feathers.
The Cooper Gang arrived in India,planning on stealing the Clockwerk Wings. Sly quietly took a look at the ballroom without being spotted. He sees the Klaww Gang Leader,Arpeggio & two members,Jean Bison & Rajan,who is the producer of the illegal spice. Carmelita,Neyla,& another INTERPOL Officer,The Contessa. Sly puts on a tuxedo without being recognized. Sly dances with Neyla to make Carmelita jealous,which therefore caused her to accept his offer for a dance. While Sly & Carmelita dance,Murray quietly steals the Clockwerk Wings. The Cooper Gang pursues Rajan in the jungle where they manage to defeat him & steals the Clockwerk Heart. The Cooper Gang are double-crossed by Neyla,who framed Carmelita.
Bentley manage to escape & travels to Prague to free Sly,Murray,& Carmelita. The Cooper Gang defeats the Contessa,stole the Clockwerk eyes,& fled with Carmelita. While tracking down Jean Bison in Canada,They make a stop at the cabin.
Next Morning, The Cooper Gang are captured by Jean Bison,who sold all the Clockwerk parts,including the lungs,stomach,& talons. After the Trio defeats him,They snuck aboard Arpeggio's blimp to confront him & Neyla,who has working with him this whole time. Arpeggio was about to merge with with Clockwerk's body,but was betrayed by Neyla,who merged with him instead to become Clock-La. After killing Arpeggio,Clock-La flies out.
Carmelita helps the Cooper Gang to stop this Mechanical hybrid by getting her to crash down. Bentley grabs Clock-La's hate chip,but his legs are crushed. Murray frees him before Clock-La exploded. Carmelita crushed the Hate Chip,killing Neyla & ending Clockwerk's reign of terra on the Cooper Clan. Sly gives himself up in exchange for letting Bentley & Murray go. Carmelita,who was given a promotion by her boss,James Barkley,took Sly on board a helicopter. Sly & Carmelita realized a short journey has taken over two hours. Sly learned that Bentley & Murray left him a parting gift by rigging the helicopter to fly circles. He escape by paragliding out of the helicopter. Carmelita remarked that she would see him soon.