Despite the Hulk saving the world with the Avengers,General Ross is still obsessed with hunting down the Hulk & wanting revenge over Betty's apparent demise. The Leader appeared & asked Ross to work with him. He has recruited the Abomination,Rhino,Absorbing Man,& Juggernaut.
Bruce was still grieving over Betty until he received a visit from his cousin,Jennifer Walters. The city was under attack and Bruce goes out as the Hulk. He fought off against the Abomination,Rhino,Juggernaut,& Absorbing Man. After Jennifer gets injured,Hulk defeats Absorbing Man,but not before Doc Samson gets captured to Siphon Hulk's energy.
With Hulk's energy & Bruce's blood combined,The Leader injects Ross,transforming him. While Jennifer is in the hospital,Bruce does a blood transfusion to save her. Bruce hears a commotion & learns that the Abomination,Rhino,& Juggernaut are at it again. Bruce transforms & fights with those three. Rhino gets defeated & Juggernaut fled.
Suddenly,A Red Monster,who was called "Red Hulk" kills the Abomination & overpowers Hulk. Jennifer senses her cousin in danger & transforms. She helps him defeat Red Hulk,who transforms back into General Ross. Ross & Rhino are arrested by S.H.I.E.L.D. & Nick Fury congratulates Banner & Jennifer,who is dubbed as She-Hulk.
Mid-Credits:
Charles Xavier came to see Fury,saying he knows about Juggernaut.
Post-Credits:
The Leader met with Baron Von Strucker to ask for HYDRA's help with creating gamma bombs.