It begins with Ryat Adams,founder of Ultratech,organized a tournament called Killer Instinct. Experimental Creatures,created by Ultratech,participated here to fight each opponent.

Jago,who was raised by the monks of the Tiger Spirit,begun meditating until the fire broke loose in the city caused by machines. The Monks urges him to find the source and prevent it from happening. He goes to the city,only to find the tournament. Jago suspecting that the machines might there,then he notice all the creatures are there until he ran into Black Orchid, aSecret Agent,& Kim Wu,a martial artist. They were later put in the tournament by Ariana,a former assistant who left in charge since Adams died. Others who can participate are Cinder,a convict criminal who turned into a living flame,Chief Thunder & his brother,Eagle,the mystical defenders of the Native People,Fulgore,a prototype cybernetic soldier developed by Ultratech,Glacius,an icy alien,Sabrewulf,a European Werewolf,Spinal,a skeleton warrior,T.J. Combo,a heavyweight champion,& Riptor,a velociraptor cloned by Ultratech.

It begins with Orchid facing Eagle and wins. Kim won against Riptor and Jago won against Sabrewulf. Cinder tries to kill Glacius,but gets overpowered and killed. Fulgore won against Spinal. Thunder fought against Combo. In the Second starts with Orchid facing Kim and wins. Jago won against Glacius. Thunder fought against Fulgore,who stabs him to death. Ariana announces that Fulgore will be advancing for the Finals.

Orchid reveals to Jago that she had been learning that She had a half brother before she was sent to investigate of what's going on at Ultratech. Jago begun to realize that the Machines will be attacking the city like in his visions. The next day,Jago & Black Orchid fought against eachother. Orchid allows him to win because She realized that Jago is her half brother. During the Final Round,Jago & Fulgore fought eachother. Orchid & Kim exposed Ultratech's goal on media. Ariana sheds her human appearance,revealing herself as ARIA,an Artificial Superintelligence created by Adams. She reveals that she killed Adams & Ariana and stole her appearance.

She prepares to launch the machines,but Kim,Glacius,Eagle,Combo,& Eagle manage to prevent it. Jago kills Fulgore and confronts ARIA. Remembering the Monks advice and the strength of the Tiger Spirit,Jago overpowered ARIA and ripped her core out,killing her. Jago return to the monks along with Orchid & Kim. As they celebrate,Kim reveals to Jago that she is the descendant of the heroes who banished evil spirits long ago.